Smoking depression, etc. reduced by Vitamin D (bi-weekly, 50,000 IU) - RCT
The effect of vitamin D supplementation on tobacco-related disorders in individuals with a tobacco use disorder: a randomized clinical trial
J Addict Dis. 2021 Dec 28;1-12. doi: 10.1080/10550887.2021.2010971
Soheil Bagheri 1, Ahmad Reza Saghazade 2, Samira Abbaszadeh-Mashkani 1, Hamid Reza Banafshe 3, Fatemeh Sadat Ghoreishi 4, Azam Mesdaghinia 3, Amir Ghaderi 4
Vitamin D deficiency in cigarette smokers (CS) might associate with several complications, including metabolic deficits, depression and anxiety. This study evaluated the effects of vitamin D on
mental health symptoms,
nicotine misuse, and
biomarkers of metabolic diseases in individuals with a tobacco use disorder.
A randomized, double-blind, placebo-controlled trial was conducted with 60 CS subjects receiving either 50,000 IU vitamin D supplements (n = 30) or placebo (n = 30) every 2 weeks for 24-weeks.
Nicotine misuse, mental health scale, and metabolic parameters were measured before and after the intervention in the CS subjects. Compared with the placebo-group, after the 24-weeks intervention, serum 25 (OH) vitamin D levels increased in the intervention group (β 2.96; 95% CI, 0.91, 5.01; P = 0.006).
In addition, vitamin D supplementation
- significantly improved Beck Depression Inventory (BDI) (β -2.06; 95% CI, -3.84, -0.28; P = 0.02).
In addition, vitamin D administration significantly decreased
fasting plasma glucose (FPG) (β -4.56; 95% CI, -8.94, -0.19; P = 0.04),
insulin (β -0.50; 95% CI, -0.88, -0.13; P = 0.009), and
homeostasis model of assessment-estimated insulin resistance (HOMA-IR) levels (β -0.21; 95% CI, -0.33, -0.08; P = 0.001).
Furthermore, vitamin D resulted in a significant elevation in
(total antioxidant capacity (TAC) (β 81.20; 95% CI, 18.30, 144.11; P = 0.01), and
- plasma glutathione (GSH) levels (β 73.05; 95% CI, 18.56, 127.54; P = 0.01), compared with the placebo-group.
Administration of vitamin D for 24-weeks to CS subjects had beneficial effects on symptoms of depression and several metabolic biomarkers. While this preliminary study suggests that vitamin D might have beneficial effects, its clinical efficacy in individuals with a tobacco use disorder should be further validated in future clinical trials.
"This study was the doctoral thesis on General Medicine (Soheil Bagheri). It has been registered with the IRCT20170420033551N7 registration code in the Iranian Center for Clinical Trials, and was supported by a grant from the Vice-chancellor for Research, KAUMS, Iran (98025)."
VitaminDWiki - Smoking reduces vitamin D - many studies
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VitaminDWiki - SMOKE or SMOKING in title (59 as of Jan 2025)
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