Senior cognition improved in 4 ways by Vitamin D (50,000 IU weekly for 8 weeks)

The effect of vitamin D on neurocognitive functions in older vitamin D deficient adults: a pilot longitudinal interventional study

Psychogeriatrics. 2023 Sep;23(5):781-788. doi: 10.1111/psyg.12997

Banu Ozulu Turkmen 1, Busra Can 2, Seda Buker 3, Birsu Beser 3, Deniz Büyükgök 3, Bahar Dernek 4, Sevilay Bovatekin 1, Pınar Kucukdagli 1, Birkan Ilhan 1, Şükriye Akça Kalem 3, Nilgun Erten 1, Mehmet Akif Karan 1, Gulistan Bahat 1

Background: The relationship between vitamin D and cognitive status remains controversial. We aimed to evaluate the effect of vitamin D replacement on cognitive functions in healthy and cognitively intact vitamin D deficient older females.

Methods: This study was designed as a prospective interventional study. A total of 30 female adults aged ≥60 with a serum 25 (OH) vitamin D level of <10 ng/ml were included. Participants were administered 50 000 IU vitamin D3 weekly for 8 weeks followed by a maintenance therapy of 1000 U/day. Detailed neuropsychological assessment was performed prior to vitamin D replacement and repeated at 6 months by the same psychologist.

Results: Mean age was 63 ± 6.7 years and baseline vitamin D level was 7.8 ± 2.0 (range: 3.5-10.3) ng/ml. At 6 months, vitamin D level was 32.5 ± 3.4 (32.2-55) ng/ml.

• The Judgement of Line Orientation Test (P = 0.04),

• inaccurate word memorizing of the Verbal Memory Processes Test (P = 0.02),

• perseveration scores of the Verbal Memory Processes Test (P = 0.005),

• topographical accuracy of the Warrington Recognition Memory Test (P = 0.002), and the

• spontaneous self-correction of an error in the Boston Naming Test (P = 0.003)

scores increased significantly, while the

• delayed recall score in the Verbal Memory Processes Test (P = 0.03),

• incorrect naming of words in the Boston Naming Test (P = 0.04),

• interference time of the Stroop Test (P = 0.05), and

• spontaneous corrections of the Stroop Test (P = 0.02)

scores decreased significantly from baseline.

Conclusion: Vitamin D replacement has a positive effect on cognitive domains related to visuospatial, executive, and memory processing functions.

Comment on inadequate follow-up dosing by VitaminDWiki:

Only 1,000 IU of vitamin D was given daily during the last 4 months
If they had instead used 50,000 IU every two weeks they would have had much better outcomes
And vitamin D levels of 40 ng instead of 30 ng

VitaminDWiki - studies in both categories Intervention - non daily and Cognition

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VitaminDWiki – Cognitive category contains

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VitaminDWiki – Overview Alzheimer's-Cognition and Vitamin D contains:

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