Resveratrol improves health (Vitamin D receptor, etc.) - many studies

Created September 2018

  • The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells

  • Resveratrol is one of 14+ ways to negate the Vitamin D Receptor restrictions

  • Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi

  • Benefits of Resveratrol, like Vitamin D, appear to be increased when used with other things

    • Quercetin and Curcumin in the case of Resveratrol

    articles in both of the categories Resveratrol and Vitamin D Receptor

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Resveratrol articles

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See also VitaminDWiki

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Vitamin D Receptor category

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Genetics category

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Influence of Resveratrol on the Immune Response (Nothing about Vitamin D) - April 2019

đź“„ Download the PDF from VitaminDWiki

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Resveratrol has a few problems for some people - Dr. Greger 4 video and transcript June 2024

Side Effects of Resveratrol Supplements Dr. Greger

  • Some studies have found that in increases LDL cholesterol by 25%

  • " Daily doses of resveratrol in excess of a gram commonly cause mild to moderate gastrointestinal symptoms, such as nausea, diarrhea, and abdominal pain, as well as “anal itchiness.”

  • "Two studies, however, found that so-called “safe” levels of resveratrol (at 150 to 250 mg a day) may blunt some of the positive effects of exercise training"

    Sources

  • Bashmakov YK, Assaad-Khalil SH, Abou Seif M, et al. Resveratrol promotes foot ulcer size reduction in type 2 diabetes patients. ISRN Endocrinol. 2014;2014:816307.

  • Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15;127(6):1109-22.

  • Moxey PW, Gogalniceanu P, Hinchliffe RJ, et al. Lower extremity amputations- - a review of global variability in incidence. Diabet Med. 2011;28(10):1144-1153.

  • Samsamikor M, Daryani NE, Asl PR, Hekmatdoost A. Resveratrol supplementation and oxidative/anti-oxidative status in patients with ulcerative colitis: a randomized, double-blind, placebo-controlled pilot study. Arch Med Res. 2016;47(4):304-309.

  • Thaung Zaw JJ, Howe PRC, Wong RHX. Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: findings from a 24-month randomized, controlled, crossover trial. Menopause. 2020;28(1):40-49.

  • Monika null, Garg R, Sardana S. Research problems associated with resveratrol (Trans-3, 5, 4’- trihydroxystilbene; rsv) and various strategies to overcome those problems(Review). Curr Drug Deliv. 2017;14(3):364-376.

  • Haghighatdoost F, Hariri M. Effect of resveratrol on lipid profile: An updated systematic review and meta-analysis on randomized clinical trials. Pharmacol Res. 2018;129:141-150.

  • Kjær TN, Ornstrup MJ, Poulsen MM, et al. No beneficial effects of resveratrol on the metabolic syndrome: a randomized placebo-controlled clinical trial. J Clin Endocrinol Metab. 2017;102(5):1642-1651.

  • Goh KP, Lee HY, Lau DP, Supaat W, Chan YH, Koh AFY. Effects of resveratrol in patients with type 2 diabetes mellitus on skeletal muscle SIRT1 expression and energy expenditure. Int J Sport Nutr Exerc Metab. 2014;24(1):2-13.

  • Cavallari I, Bhatt DL, Steg PG, et al. Causes and risk factors for death in diabetes: a competing-risk analysis from the savor-timi 53 trial. J Am Coll Cardiol. 2021;77(14):1837-1840.

  • Tang PCT, Ng YF, Ho S, Gyda M, Chan SW. Resveratrol and cardiovascular health- - promising therapeutic or hopeless illusion? Pharmacol Res. 2014;90:88-115.

  • Visioli F, Panaite SA, TomĂ©-Carneiro J. Wine’s phenolic compounds and health: a pythagorean view. Molecules. 2020;25(18):4105.

  • Wilson T, Knight TJ, Beitz DC, Lewis DS, Engen RL. Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits. Life Sci. 1996;59(1):PL15-21.

  • Gliemann L. What are the chances that resveratrol will be the drug of tomorrow? Pharmacol Res. 2018;129:139-140.

  • Semba RD, Ferrucci L, Bartali B, et al. Resveratrol levels and all-cause mortality in older community-dwelling adults. JAMA Intern Med. 2014;174(7):1077-1084.

  • Wahab A, Gao K, Jia C, et al. Significance of resveratrol in clinical management of chronic diseases. Molecules. 2017;22(8):1329.

  • Patel KR, Scott E, Brown VA, Gescher AJ, Steward WP, Brown K. Clinical trials of resveratrol. Ann N Y Acad Sci. 2011;1215:161-169.

  • Shaito A, Posadino AM, Younes N, et al. Potential adverse effects of resveratrol: a literature review. Int J Mol Sci. 2020;21(6):2084.

  • Popat R, Plesner T, Davies F, et al. A phase 2 study of SRT501 (Resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma. Br J Haematol. 2013;160(5):714-717.

  • Gliemann L, Schmidt JF, Olesen J, et al. Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. J Physiol. 2013;591(20):5047-5059.

  • Scribbans TD, Ma JK, Edgett BA, et al. Resveratrol supplementation does not augment performance adaptations or fibre-type-specific responses to high-intensity interval training in humans. Appl Physiol Nutr Metab. 2014;39(11):1305-1313.

  • Meng X, Zhou J, Zhao CN, Gan RY, Li HB. Health benefits and molecular mechanisms of resveratrol: a narrative review. Foods. 2020;9(3):340.

  • Thaung Zaw JJ, Howe PR, Wong RH. Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study. Clin Nutr. 2021;40(3):820-829.

  • Morris BJ. Seven sirtuins for seven deadly diseases of aging. Free Radic Biol Med. 2013;56:133-171.

  • Timmers S, Konings E, Bilet L, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011;14(5):612-622.

  • Visioli F. The resveratrol fiasco. Pharmacol Res. 2014;90:87.

  • Tang PCT, Ng YF, Ho S, Gyda M, Chan SW. Resveratrol and cardiovascular health - promising therapeutic or hopeless illusion? Pharmacol Res. 2014;90:88-115.

  • Pezzuto JM. Resveratrol: twenty years of growth, development and controversy. Biomol Ther (Seoul). 2019;27(1):1-14.

  • Gliemann L, Olesen J, Biensø RS, et al. Reply from Lasse Gliemann, Jesper Olesen, Rasmus Sjorup Bienso, Stefan Peter Mortensen, Michael Nyberg, Jens Bangsbo, Henriette Pilegaard and Ylva Hellsten. J Physiol. 2014;592(3):553.

Resveratrol does not appear to extend life (many studies since 1991) - Dr. Greger June 2024

video and text summary with about 50 references

Multiplicity of effects and health benefits of resveratrol – April 2015

Medicina 2016, 52(3), 148-155; https://doi.org/10.1016/j.medici.2016.03.003

by Lolita Kuršvietienė 1,*,Inga Stanevičienė 1,2,Aušra Mongirdienė 1,3 andJurga Bernatonienė 4

1 Department of Biochemistry, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

2 Laboratory of Molecular Neurobiology, Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

3 Laboratory of Molecular Cardiology, Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

4 Department of Drug Technology and Social Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

Resveratrol is mainly found in grapes and red wine, also in some plants and fruits, such as peanuts, cranberries, pistachios, blueberries and bilberries. Moreover, nowadays this compound is available as purified preparation and dietary supplement. Resveratrol provides a wide range of benefits, including

  • cardiovascular protective,

  • antiplatelet,

  • antioxidant,

  • antiinflammatory,

  • blood glucose-lowering and

  • anticancer activities,

hence it exhibits a complex mode of action. During the recent years, these properties have been widely studied in animal and human models, both in vitro and in vivo. This paper is intended to present information published during the recent years on the biological activities and multiple effects of resveratrol.

đź“„ Download the PDF from VitaminDWiki

PubMed (3X increase in publications which include the word RESVERATROL in 13 years))

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  • Resveratrol: Twenty Years of Growth, Development and Controversy - Jan 2019

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  • Resveratrol potentiates vitamin D and nuclear receptor signaling - June 2015, doi: 10.1002/jcb.25070

  • Enhancing the Delivery of Resveratrol in Humans:If Low Bioavailability is the Problem, What is the Solution? - 2014

  • Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis Sept 2018, doi: 10.1016/j.arr.2018.05.004

  • Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice. 2017 10.2174/1567205014666170207093455

  • New strategies in sport nutrition to increase exercise performance Sept 2016 doi: 10.1016/j.freeradbiomed.2016.01.016 free PDF

  • New concepts and challenges in the clinical translation of cancer preventive therapies: the role of pharmacodynamic biomarkers Nov 2015 doi: 10.3332/ecancer.2015.601 free PDF

  • Nutritional treatment for acute and chronic traumatic brain injury patients Sept 2014

    • They found improvements by Reseveratrol, Omega-3, Magnesium, all of which improve the amount of Vitamin D getting to cells

  • Resveratrol: A Double-Edged Sword in Health Benefits Sept 2018 10.3390/biomedicines6030091

  • Resveratrol-loaded nanoemulsion prevents cognitive decline after abdominal surgery in aged rats Aug 2018 doi: 10.1016/j.jphs.2018.08.006

  • Increased Oral Bioavailability of Resveratrol by Its Encapsulation in Casein Nanoparticles doi Sept 2018 10X increase in bio-availability

  • Developmental Programming of the Metabolic Syndrome: Can We Reprogram with Resveratrol? Aug 2017 doi: 10.3390/ijms19092584 free PDF

  • Resveratrol and Depressio n in Animal Models: A Systematic Review of the Biological Mechanisms| Aug 2018 10.3390/molecules23092197 free PDF

  • Resveratrol Supplementation Reduces Pain and Inflammation in Knee Osteoarthritis Patients Treated with Meloxicam: A Randomized Placebo-Controlled Study Aug 2018 10.1089/jmf.2017.4176

  • Resveratrol Counteracts Insulin Resistance -Potential Role of the Circulation Aug 2018 doi: 10.3390/nu10091160 free PDF

  • Resveratrol: an effective pharmacological agent to prevent inflammation-induced atrial fibrillation ? Sept 2017 doi: 10.1007/s00210-018-1566-5 Free PDF

  • Resveratrol prevents atrial fibrillation by inhibiting atrial structural and metabolic remodeling in collagen-induced arthritis rats Aug 2018 doi: 10.1007/s00210-018-1554-9

  • Pleiotropic mechanisms facilitated by resveratrol and its metabolites - July 2010

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Web

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summarized from: Long-Term Resveratrol Supplementation as a Secondary Prophylaxis for Stroke

đź“„ Download the PDF from VitaminDWiki

Found My Fitness ( Dr. Patrick) on Reseveratrol

Resveratrol - 2019?

1Resveratrol's effects on human health and disease

1.1Metabolic and cardiovascular health and markers of inflammation

1.2Neurological health and Alzheimer’s disease

1.3Cancer

1.4Longevity

2 Physiological responses and molecular mechanisms associated with resveratrol intake

2.1Sirtuin activation

2.2Autophagy activation

2.3Resveratrol as an insect antifeedant and its role in xenohormesis

2.4Resveratrol as a calorie restriction mimetic

2.5Exercise performance enhancement from resveratrol

2.6Resveratrol supplementation and safety

3Conclusion

•Resveratrol news

Podcast Jan 2020 - for subscribers only

00:03:39 - Clinical effects of resveratrol in humans

00:04:10 - Effects on cardiovascular health biomarkers in humans

00:06:54 - Reduction of inflammatory biomarkers in humans

00:08:11 - Improved cognition and memory in clinical studies

00:11:23 - Healthspan improvements in animals

00:12:28 - Induction of longevity genes via xenohormesis

00:16:19 - Contradictory effects on exercise-associated benefits

00:20:34 - Various factors that affect resveratrol bioavailability

00:23:09 - Unintentional effects on drug metabolism

    no apparent mention that Resveratrol increases the Vitamin D Receptor

Resveratrol overview at Examine.com July 2024

Extensive overview

  • "The therapeutic dose of resveratrol ranges from 8.1 mg per day to 3,000 mg per day.
    Studies in humans suggest resveratrol can be supplemented at dosages up to 5 grams (5,000 mg) daily with few to no side effects outside of some intestinal upset and nausea."

Does not appear to mention that it is an activator of the Vitamin D receptor, nor mention the more bio-available forms of Resveratrol

RESVERATROL: REWRITING THE SCIENCE, Oct, 2018: by Bill Sardi

F|Excellent material - but he had me remove even the table of contents from VitaminDWiki May 2020

Chart of Resveratrol benefits - Natural Biology

They sell it

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Resveratrol, being a phytoestrogen, DECREASED Breast Cancer survival by 19% - Nov 2019

Increasing levels of resveratrol, genistein, or luteolin linked to worse five-year breast cancer survival

Resveratrol oral and topical forms that are more bio-available

Strategies to Improve Resveratrol Systemic and Topical Bioavailability: An Update - July 2019

đź“„ Download the PDF from VitaminDWiki

No mention of the Vitamin D Receptor

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Asked ChatGPT: What are the downsides to taking Resveratrol - Dec 2023

Resveratrol, a polyphenol found in certain plants and fruits, is often taken as a supplement for its potential health benefits. However, like any supplement, resveratrol can have downsides and side effects, particularly at higher doses or when taken in certain circumstances:

  1. Gastrointestinal Issues : High doses of resveratrol can cause gastrointestinal side effects such as nausea, diarrhea, vomiting, and other digestive issues. These effects are generally associated with doses higher than those achievable through diet alone, often occurring with supplement consumption 1  2

  2. Drug Interactions : Resveratrol may interact with several medications. It can inhibit cytochrome 3A4, potentially causing interactions with a range of medications including HMG-CoA reductase inhibitors (used to lower cholesterol), calcium channel agonists, anti-arrhythmic agents, HIV protease inhibitors, immunosuppressants, antihistamines, and erectile dysfunction medications. Additionally, its natural blood pressure-lowering and anti-coagulant effects might interact with blood pressure medications, anti-platelet drugs, anticoagulants, and NSAIDs like aspirin and ibuprofen 3  4

  3. Estrogenic Effects : Resveratrol has shown both estrogen agonist and antagonist effects in cell culture studies, and its chemical structure is similar to synthetic estrogen agonists. This characteristic can be problematic for individuals with estrogen-dependent tumors, such as those found in prostate and breast cancers. These tumors have many estrogen receptors and rely on the hormone for growth. Hence, individuals at risk for tumor growth should be cautious about concentrated resveratrol supplements 5  6 .

  4. Joint Pain and Tendinitis : Some people have reported joint pain and tendinitis with resveratrol use, commonly affecting the Achilles tendon and other joint areas, sometimes accompanied by tingling and numbness in limbs 7  8

  5. Other Potential Side Effects : These include jittery feelings similar to excessive caffeine intake, insomnia, flu-like symptoms such as muscle aches and cramps, blood in the urine, and, in rare cases, an increase in arthritis pain. These symptoms are not universally experienced and may vary from person to person 9 .

It's important to note that while some of these side effects are more commonly reported, others are rare or based on anecdotal evidence. The overall safety and side effects can vary greatly depending on the individual, the dosage, and other factors such as concurrent medication use or existing health conditions. Always consult a healthcare professional before starting any new supplement regimen, including resveratrol, to ensure it is safe based on your personal health profile.

Turmeric is as Effective as 14 Drugs (Turmeric also increases VDR activation) - March 2021

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Associations with: Vitamin D Receptor, Virus, Zinc, Omega-3, Vitamin C, Cognitive, Magnesium, Vitamin K, Curcumin, Boron

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