Preterm Births - promising preventions ā anti-oxidants, Vitamin D, Omega-3, Zinc, etc.
Research prioritization of interventions for the primary prevention of preterm birth: An international survey
Eur J Obstet Gynecol Reprod Biol. 2019 Jan 25. pii: S0301-2115(19)30048-X. doi: 10.1016/j.ejogrb.2019.01.021.
Allotey J1, Matei A2, Husain S3, Newton S4, Dodds J5, Armson AB2, Khan KS5, Vogel JP6.
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International Survey ranked the possibilities
Vitamin D was the only supplement which was a research priority
Note: For thousands of years pregnancies averaged 40 weeks
In 2006 March of Dimes stated the average pregnancy lasted only 39 weeks (new average)
š Download the PDF from Sci-Hub via VitaminDWiki
OBJECTIVE:
To identify research priorities of interventions for the primary prevention of preterm birth (PTB), by conducting an international stakeholder survey.
STUDY DESIGN:
A prospective cross-sectional online survey was conducted in November 2016. Fifteen interventions to prevent spontaneous PTB were identified and ranked by stakeholders (nā=ā159) in the field of maternal and perinatal health research, using nine equally weighted criteria. Medians and interquartile ranges (IQRs) were calculated and the interventions ranked accordingly.
RESULTS:
Respondents to the survey were from 46 different countries, mostly from low and middle-income countries (62%, 99/159) and were mainly clinicians (80%, 127/159).
Of the fifteen interventions ranked, the following five were identified as research priorities in the primary prevention of PTB:
dietary counselling and nutritional education,
risk scoring,
vitamin D supplementation,
exercise and
antioxidant supplementation.
Criteria
CONCLUSION:
We have identified research priorities of interventions to prevent spontaneous PTB through a global stakeholder survey. The interventions prioritized in this exercise can be used by researchers, grant funding bodies and research-policy decision makers to inform calls on future clinical trials or individual patient data meta-analyses on the primary prevention of PTB.
Top 8 promising interventions to reduce pre-term births
| 1 | Antioxidants 1 | Supplementation | Regular antenatal dietary supplementation of one or more antioxidants such as vitamin C |
| 2 | Vitamin D 2 | Supplementation | Regular antenatal dietary supplementation of vitamin D either alone or in combination with other supplements |
| 3 | Vitamin E 3 | Supplementation | Regular antenatal dietary supplementation of vitamin E either alone or in combination with other supplements |
| 4 | Omega-3/fish oil 4 | Supplementation | Regular antenatal dietary supplementation of Omega-3/fish oil capsules |
| 5 | Zinc 5 | Supplementation | Regular antenatal dietary supplementation of zinc either alone or in combination with other supplements |
| 6 | Aspirin 6 | Supplementation | Low-dose aspirin therapy with or without dipyridamole |
| 7 | Probiotics 7 | Supplementation | Regular administration of probiotics as pessaries capsules, tablets or powder |
| 8 | Antibiotics prophylaxis 8 | Treatment of infection | Routine antibiotics given during the second and third trimesters to prevent vaginal or cervical infections |
VitaminDWiki Pregnancy pages with PRETERM of PRE-TERM in title (61 as of May 2022)
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