Preeclampsia risk reduced 60 percent if supplement with Vitamin D (they ignored dose size) – meta-analysis

Vitamins supplementation affects the onset of preeclampsia.

J Formos Med Assoc. 2017 Sep 3. pii: S0929-6646(17)30368-6. doi: 10.1016/j.jfma.2017.08.005. [Epub ahead of print]

Virtually all meta-analyses amazingly ignore dose sizes of Vitamin D and Calcium Meta-analysis gives same weight to dose = 400 IU and dose = 4,000 IU They also ignored existing levels of Vitamin D Risk Ratio = 0.41, was NOT statistically significant. 1. Preeclampsia highlights * Preeclampsia recurrence reduced 2 X by 50,000 IU of vitamin D every two weeks – RCT July 2017 * Preeclampsia reduced by Vitamin D (50,000 IU bi-weekly) and Calcium – Oct 2015 * Preeclampsia rate cut in half by high level of vitamin D – meta-analysis March 2014 * Preeclampsia 2.7X more frequent if low vitamin D – meta-analysis Sept 2013 1. All pages listed in BOTH the categories Pregnancy and Hypertension (preeclampsia) {category} 1. Healthy pregnancies need lots of vitamin D has the following summary {include} Vitamin D charts from GrassrootsHealth - May 2016 has the following chart

📄 Download the PDF from VitaminDWiki

Fu ZM1, Ma ZZ2, Liu GJ1, Wang LL1, Guo Y3.

• 1 Maternity Department, W.F. Maternity and Child Care Hospital, 407 Qingnian Road, Weicheng District, Weifang 261011, China.

• 2 Pharmacy Department, Weifang People's Hospital, 151 Guangwen Street, Kuiwen District, Weifang 261041, China.

• 3 Maternity Department, W.F. Maternity and Child Care Hospital, 407 Qingnian Road, Weicheng District, Weifang 261011, China. Electronic address: Guoywf@163.com.

Preeclampsia may affect between 2-8% of all pregnancies. It seriously affects maternal health after pregnancy. This meta-analysis was performed to define the efficacy of vitamins supplementation on the risk of preeclampsia. Potential articles were systematically searched on the databases of Pubmed, Embase and Web of Science up to May 2016. Relative risk (RR) and 95% confidence intervals (95%CIs) were used to analyze the relationship of vitamins supplementation with risk of preeclampsia. Cochran Q test was used to test inter-study heterogeneity. Begg's funnel plot was adopted to assess the potential publication bias. 28 eligible studies were selected. Pooled results indicated that vitamins supplementation could reduce the risk of preeclampsia (RR = 0.74, 95%CI = 0.64-0.86). The studies with non-randomized controlled trial (RCT) analysis also suggested the significant relationship of vitamins supplementation with risk of preeclampsia (RR = 0.60, 95%CI = 0.42-0.85). However, negative results were observed in studies with RCT analysis. Subgroup analysis by vitamin type was performed among the studies with RCT analysis.

The results indicated that vitamin D supplementation could significantly reduce the risk of preeclampsia ( RR = 0.41 , 95%CI = 0.22-0.78). Similar results were observed in the studies with multivitamins supplementation (RR = 0.69, 95%CI = 0.51-0.93). Vitamins supplementation could reduce the onset of preeclampsia.

PMID: 28877853 DOI: 10.1016/j.jfma.2017.08.005