Poor responses to UV and Vitamin D were correlated to just 4 poor genes

Created June 2019

Serum 25(OH)D levels after oral vitamin D3 supplementation and UVB exposure correlate.

Photodermatol Photoimmunol Photomed. 2019 Jun 5. doi: 10.1111/phpp.12491.

Datta P1, Philipsen PA1, Olsen P1, Andersen JD2, Morling N2, Wulf HC1.

* It is well known that the response to Vitamin D and UVB varies by up to 4X between individuals * Until this paper there was little clue as to the reason for the different responses * The same individuals were given 3400 IU and UVB (at different times) which on average resulted in increase blood level of 21 ng * It appears that those having a low response to Vitamin D also has a low response to UVB, etc. * Just 4 gene modifications (SNIPS) are able to characterize 87% of the individual differences in the responses --- * Overview Vitamin D Dose-Response many charts of different responses to the same Vitamin D dose * Some people need more vitamin D to get the same response – perhaps due to genes – Nov 2014 * Huge variation in response to vitamin D supplementation – personal vitamin D response index – Dec 2016 * 10 reasons for poor response to Vitamin D (race, binding protein, etc.) – Nov 2017 * Reasons for low response to vitamin D * Poor absorption of Vitamin D is strongly related to type of gut bacteria – Dec 2020 * On-line Vitamin D response simulation – July 2021 * VitaminDWiki page titles containing "RESPONSE" 127 pages as of Oct 2021 Items in both categories Genetics and Predict Vitamin D are listed here: {category} Response to UV * Response to UV varies more with pigment genes and age than skin color – Jan 2019 * Large variability in response to UV (more than response to oral Vitamin D) – March 2016

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BACKGROUND: The inter-individual variation in 25(OH)D3 increase (Δ25(OH)D3 ) after vitamin D3 supplementation was determined and compared the UVB irradiation.

METHODS: Nineteen Danish participants received 85 μg vitamin D3 (cholecalciferol) daily for nine weeks with regular serum 25(OH)D3 measurements. These participants had three years earlier taken part in a 9-week controlled UVB study. The Δ25(OH)D3 was not confounded by ambient UVB, BMI or ethnicity.

RESULTS:

Δ25(OH)D3 was 53 nmol l-1 and almost identical to Δ25(OH)D3 (52 nmol l-1 ) after UVB. Δ25(OH)D3 ranged from 17 to 91 nmol l-1 (span 74 nmol l-1 ) and was about half of that observed after UVB irradiation (span 136 nmol l-1 ). The interquartile ranges for vitamin D3 supplementation (38.8-71.4 nmol l-1 , span: 32.6 nmol l-1 ) and UVB irradiation (35.7-65.4 nmol l-1 , span: 29.7 nmol l-1 ) were similar indicating a comparable response of the two interventions. As the 25(OH)D3 start levels (R2 = 0.398, P = 3.8 × 10-3 ), 25(OH)D3 end levels (R2 = 0.457, P = 1.5 × 10-3 ) and Δ25(OH)D3 (R2 = 0.253, P = 0.028) between both interventions were correlated, this suggested a possible common individual background for the variation. Four pigment SNPs influenced the variation in the vitamin D3 -induced and UVB-induced Δ25(OH)D3 . A combined model including the influence of these four SNPs and the 25(OH)D3 start level explained 86.8% (P = 1.6×10-35 ) of the individual variation after vitamin D3 supplementation.

CONCLUSION: The inter-individual variation in the two interventions was comparable and had no common demographic but a partly common genetic background.

Tags: Predict UV