Most people with Long-Haul COVID-19 have low Vitamin D

Investigating the Relationship between Vitamin D and Persistent Symptoms Following SARS-CoV-2 Infection

Nutrients 2021, 13(7), 2430; https://doi.org/10.3390/nu13072430

by Liam Townsend 1,2,*OrcID,Adam H. Dyer 3OrcID,Patrick McCluskey 4,Kate O’Brien 5,Joanne Dowds 5,Eamon Laird 3,6OrcID,Ciaran Bannan 1,2,Nollaig M. Bourke 3,Cliona Ní Cheallaigh 1,2OrcID,Declan G. Byrne 2,4OrcID andRose Anne Kenny 6,7

Long-Haul = Long-COVID = post-acute sequelae of SARS-CoV-2 infection, (PASC) has many overlaps with previous SARS-2003, Fibromyalgia, POTS,and some infectious diseases Atlantic Sept 1, 2021 Study assumes that a 30 ng level is sufficient - it is not! Note: Most people with >40 ng appear to not get COVID-19 or long haul Study ignores that the vitamin D receptor can restrict vitamin D in the blood from getting to cells Vitamin D levels had been >50 ng Click on chart for details 1. Pages in both of the categories Virus and Vitamin D Receptor: {category} The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019 {FONT(size="18")}Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc{FONT}  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators__ 1. See "long-haul" in VitaminDWiki titles {LIST()}

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The emergence of persistent symptoms following SARS-CoV-2 infection, known as long COVID, is providing a new challenge to healthcare systems. The cardinal features are fatigue and reduced exercise tolerance. Vitamin D is known to have pleotropic effects far beyond bone health and is associated with immune modulation and autoimmunity. We hypothesize that vitamin D levels are associated with persistent symptoms following COVID-19. Herein, we investigate the relationship between vitamin D and fatigue and reduced exercise tolerance, assessed by the Chalder Fatigue Score, six-minute walk test and modified Borg scale. Multivariable linear and logistic regression models were used to evaluate the relationships. A total of 149 patients were recruited at a median of 79 days after COVID-19 illness. The median vitamin D level was 62 nmol/L, with n = 36 (24%) having levels 30–49 nmol/L and n = 14 (9%) with levels <30 nmol/L. Fatigue was common, with n = 86 (58%) meeting the case definition. The median Borg score was 3, while the median distance covered for the walk test was 450 m. No relationship between vitamin D and the measures of ongoing ill-health assessed in the study was found following multivariable regression analysis. These results suggest that persistent fatigue and reduced exercise tolerance following COVID-19 are independent of vitamin D.