Long-COVID fatigue, anxiety, and cognition treated by 60,000 IU of vitamin D weekly – RCT
Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial
Psychiatry Clin Neurosci. 2024 Jul 28. doi: 10.1111/pcn.13716 PDF is behind a paywall – but references are not behind paywall
Veevarin Charoenporn 1 2 3, Parunkul Tungsukruthai 3, Pitchapa Teacharushatakit 4, Sirashat Hanvivattanakul 4, Kusuma Sriyakul 3, Sophida Sukprasert 3, Chuntida Kamalashiran 3, Sucharat Tungsukruthai 5, Thammanard Charernboon 1 6
Aim: This study evaluated the effectiveness of high-dose vitamin D supplementation in alleviating fatigue and neuropsychiatric symptoms in post-COVID syndrome.
Methods: In an 8-week, double-blind, randomized, placebo-controlled trial, 80 patients with post-COVID fatigue or neuropsychiatric symptoms were enrolled. Participants were randomly assigned to receive either 60,000 IU of vitamin D weekly (n = 40) or a placebo (n = 40) for 8 weeks. Clinical outcomes were assessed using the 11-item Chalder Fatigue Scale (CFQ-11) ; 21-item Depression, Anxiety, and Stress Scale (DASS-21); Pittsburgh Sleep Quality Index (PSQI); Addenbrooke's Cognitive Examination III (ACE) ; and Trail Making Test A and B (TMT-A and TMT-B). Baseline and 8-week measurements of inflammatory markers, including interleukin 6 (IL-6) and C-reactive protein (CRP), were also collected.
Results: Significant improvements were found in the vitamin D group for
CFQ (coefficient -3.5, P = 0.024),
DASS-anxiety (-2.0, P = 0.011), and
ACE (2.1, P = 0.012).
No significant differences were observed in PSQI, DASS-depression, TMT, IL-6, or CRP levels. The incidence of adverse events was comparable between groups, with no serious adverse events reported.
Conclusion: High-dose vitamin D supplementation may benefit patients with post-COVID syndrome by reducing fatigue, alleviating anxiety, and improving cognitive symptoms, with minimal side effects.
VitaminDWiki - 50,000 IU of Vitamin D - many studies
VitaminDWiki – Additional health problems fought by 50,000 IU weekly
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