Kidney cancer 22 percent less likely if high vitamin D – meta-analysis

Examining the association of circulating 25-hydroxyvitamin D with kidney cancer risk: a meta-analysis

Int J Clin Exp Med. 2015; 8(11): 20499–20507. Published online 2015 Nov 15, PMCID: PMC4723811

Guangzheng Lin,1,* Ling Ning,2,* Di Gu,1,* Shi Li,1 Zhe Yu,1 Qicheng Long,1 Li-Na Hou,3 and Wan-Long Tan1

Note: 1. No indication of how many years elapsed (if any) between Vitamin D test and kidney cancer diagnosis 1. No indication if kidney was failing before kidney cancer, and thus not producing active vitamin D needed to fight cancer 1. All studies “corrected” for smoking and BMI status. * But recall that both greatly reduces vitamin D levels. Wonder how they made their “correction” 1. All studies ignored the effect of genes - a 5X effect - see below Suspect vitamin D actual protection against Kidney Cancer is actually much higher – perhaps similar to 10+ other cancers: > 60%, not just 22%, especially if use a form of Vitamin D which does not require Kidney activation See also VitaminDWiki * 5X less risk of Kidney cancer if good ratio of Vitamin D binding protein to circulating vitamin D – Nov 2013 * Smoking reduces vitamin D - many studies Many ways to increase Vitamin D such as Calcitriol, Omega-3, and a purple herb for Kidney problems click on chart for details Huge decrease in cancers as increase vitamin D

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Objective: To examine the relationship between circulating 25-hydroxy-vitamin D (25 (OH) D) and risk of kidney cancer. Methods: We searched PubMed, EMBASE, and Web of Science databases through August 31, 2015 for eligible studies. Pooled ORs with 95% confidence interval were calculated using fixed effect models. All data analyses were performed with STATA version 12.0.

Results: The final analysis included 2 prospective cohort studies and 7 nested case-control studies, with a total of 130, 609 participants and 1, 815 cases of kidney cancer. No obvious heterogeneity was observed between individual studies. The results of this study revealed that higher circulating 25-hydroxyvitamin D levels were associated with lower risk of kidney cancer (OR=0.79, 95% CI 0.69-0.91; P value for heterogeneity: 0.61, I2=0%). After stratified by geographical region, the similar association was detected in European studies (OR=0.81, 95% CI 0.69-0.94; P value for heterogeneity: 0.38, I2=0%), though no significant association was observed in the USA studies (OR=0.73, 95% CI 0.51-1.04; P value for heterogeneity: 0.44, I2=0%).

Conclusion: Our present findings suggest that higher levels of circulating 25-hydroxyvitamin D could reduce the risk of kidney cancer by 21%. Further well-designed large-scaled prospective studies and randomized controlled trials are warranted to provide more conclusive evidence.