Infant and child immunity depends on Vitamin D and two Vitamin D genes – Review

Created April 2020

Vitamin D and Immunity in Infants and Children

Nutrients 2020, 12, 1233; doi:10.3390/nu12051233

Geneviève Mailhot and John H. White

Vitamin D signaling in innate immunity

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Highlights added by VitaminDWiki

1. Vitamin D Genes Vitamin D Receptor is associated in over 58 autoimmune studies The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019 * Omega-3,  Magnesium, Zinc,  Quercetin,  non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc**  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators 1. CYP27B1 category listing contains the following {include} 1. # Items in both categories Infant-Child and VDR are listed here: {category} --- 1. # Items in both categories Infant-Child and Immunity are listed here: {category} 1. # Items in both categories Infant-Child and Diabetes are listed here: {category} 1. # Items in both categories Infant-Child and Multiple Sclerosis are listed here: {category} 1. # Items in both categories Infant-Child and Breathing are listed here: {category} 1. Overview Asthma and Vitamin D contains {include}

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The last couple of decades have seen an explosion in our interest and understanding of the role of vitamin D in the regulation of immunity. At the molecular level, the hormonal form of vitamin D signals through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription factor. The VDR and vitamin D metabolic enzymes are expressed throughout the innate and adaptive arms of the immune system. The advent of genome-wide approaches to gene expression profiling have led to the identification of numerous VDR-regulated genes implicated in the regulation of innate and adaptive immunity. The molecular data infer that vitamin D signaling should boost innate immunity against pathogens of bacterial or viral origin. Vitamin D signaling also suppresses inflammatory immune responses that underlie autoimmunity and regulate allergic responses. These findings have been bolstered by clinical studies linking vitamin D deficiency to increased rates of infections, autoimmunity, and allergies. Our goals here are to provide an overview of the molecular basis for immune system regulation and to survey the clinical data from pediatric populations, using randomized placebo-controlled trials and meta-analyses where possible, linking vitamin D deficiency to increased rates of infections, autoimmune conditions, and allergies, and addressing the impact of supplementation on these conditions.

Partial Table of Contents

  • 2. Overview of the Molecular Basis for the Non-Classical Actions of Vitamin D in the Immune System

    • Antiviral Activity of Vitamin D Signaling: Specific Reference to COVID-19.

  • 3. Vitamin D and Infectious Diseases in Pediatric Populations.

  • 4. Crohn’s Disease

  • 5. Vitamin D Deficiency and Dental Caries

  • 6. Links between Vitamin D Deficiency and Autoimmune Conditions in Pediatric Populations.

    • 6.1. Juvenile-Onset Type 1 Diabetes.

    • 6.2. Multiple Sclerosis

    • 6.3. Other Autoimmune Conditions

  • 7. Allergic Conditions

    • 7.1. Asthma

    • 7.2. Other Allergic Conditions

      • 7.2.1. Atopic Dermatitis

      • 7.2.2. Food Allergies

      • 7.2.3. Allergic Rhinitis and Aeroallergen Sensitization

Tags: CYP27B1 Immunity Infant-Child Vit D Receptor