Higher vitamin D levels associated with health and lower risk of atrial fibrillation
Vitamin D and the Risk of Atrial Fibrillation - The Rotterdam Study
PLOS ONE: May 1, 2015DOI: 10.1371/journal.pone.0125161
Anna Vitezova , Natasha S. Cartolano , Jan Heeringa, M. Carola Zillikens, Albert Hofman, Oscar H. Franco, Jessica C. Kiefte-de Jong
Atrial fibrillation (AF) is the most common chronic arrhythmia and it increases the risk of cardiovascular morbidity and mortality. Still there is not a complete understanding of its etiology and underlying pathways. Vitamin D might regulate renin-angiotensin-aldosterone system and might be involved in inflammation, both implicated in the pathophysiology of AF. The objective of this work was to investigate the association between vitamin D status with the risk of AF in the elderly. This study was conducted within the Rotterdam Study, a community-based cohort of middle-aged and elderly participants in Rotterdam, The Netherlands. We had 3,395 participants who were free of AF diagnosis at the start of our study and who had vitamin D data available. We analyzed the association between serum 25-hydroxivitamin D (25(OH)D) and incidence of AF using Cox regression models. Vitamin D deficiency was defined as serum 25(OH)D concentrations <50nmol/l, insufficiency between 50nmol/l and 75nmol/l, while serum 25(OH)D concentrations equal to and above 75nmol/l were considered as adequate.
After mean follow-up of 12.0 years 263 (7.7%) participants were diagnosed with incident AF. Vitamin D status was not associated with AF in any of the 3 multivariate models tested (model adjusted for socio-demographic factors and life-style factors: HR per 10 unit increment in serum 25(OH)D 0.96, 95% CI: 0.91-1.02; HR for insufficiency: 0.82, 95%CI: 0.60-1.11,and HR for adequate status: 0.76, 95%CI: 0.52-1.12 compared to deficiency). This prospective cohort study does not support the hypothesis that vitamin D status is associated with AF.
VitaminDWiki summary table of data above
Risk reduction per 10 nmol additional vitamin D
||Deficiency: < 50 nmol| 0 %
Insufficiency: 50-75 nmol| - 4%
Adequate: > 75 nmol|- 24%
| Observation: |
| The data appears to strongly support a reduction in AF with increased vitamin D |
| How do the authors claim otherwise? |
| Perhaps because there was not enough data to prove significance of the results? |
At baseline:Those with higher levels of vitamin D were healthier
| |
| | | Deficient | Insufficient | Adequate
| <50nmol/l | 50-75nmol/l | >75nmol/l | | Serum 25(OH)D nmol/l | 31.4 | 61.1 | 93.1 | | AF incidence | 8.6% | 6.7% | 6.4% | | Current smokers | 17.2% | 14.1% | 15.7% | | Presence of Diabetes | 17.2% | 11.6% | 8.8% | | Presence of CVD | 16.2% | 12.8% | 11.7% | | Use of lipid lowering drugs | 15.7% | 14% | 14.6% |
đź“„ Download the PDF from VitaminDWiki
See also VitaminDWiki
Arrhythmia OR “atrial fibrillation” 130 items as of Feb 2015
(Arrhythmia OR “atrial fibrillation”) AND Magnesium 60 items as of Feb 2015
Cardiovascular category listing has items along with related searches