Gestational Diabetes treated with 50,000 IU every two weeks – RCT
Effect of various doses of vitamin D supplementation on pregnant women with gestational diabetes mellitus: A randomized controlled trial
Experimental and Theraputic Medicine, September 2016, Volume 12 Issue 3, DOI: 10.3892/etm.2016.3515
Qingying Zhang Yan Cheng Mulan He Tingting Li Ziwen Ma Haidong Cheng
HOMA-IR
TAC (antioxident)
GSH (antioxident)
GDM detected before week 12
Dosing from week 24-28 of pregnancy to women not getting any other treatment
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| --- | --- | --- | --- | --- |
| | Control | Low dose | Medium Dose | High dose |
| Dose | 0 | 200 IU daily | 50,000 IU every 4 weeks | 50,000 IU
every 2 weeks | | Avg daily | 0 IU | 200 IU | 1,800 IU | 3,600 IU | See also VitaminDWiki * One pill every two weeks gives you all the vitamin D most adults need 50.000 IU every 2 weeks * 4000 IU Vitamin D Safe and Effective For Healthy Pregnant Women – RCT June 2011 * Women taking 4,000 IU reduced pregnancy risks in half RCT May 2010 Pages listed in BOTH the categories Diabetes and Pregnancy {category} Healthy pregnancies need lots of vitamin D has the following summary {include}
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It has previously been reported that the influence of vitamin D on the metabolism of calcium and phosphorus is associated with diabetes, cardiovascular disease, Alzheimer's disease, cancer and other systemic diseases, and is considered an important indicator of general health. The present study was conducted to determine the effect of various doses of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation and the levels of oxidative stress of pregnant women with gestational diabetes mellitus (GDM). The present randomized, double-blind placebo-controlled clinical trial was conducted on 133 pregnant women with GDM during weeks 24-28 of pregnancy. The patients were randomly divided into four groups. The control group (n=20) received a placebo (sucrose; one granule/day), the low dosage group (n=38) received the daily recommended intake of 200 IU vitamin D (calciferol) daily, the medium dosage group (n=38) received 50,000 IU monthly (2,000 IU daily for 25 days) and the high dosage group (n=37) received 50,000 IU every 2 weeks (4,000 IU daily for 12.5 days). The general characteristics and dietary intakes of the patients with GDM were similar between each group. Using ELISA kits, it was determined that insulin, homeostatic model assessment-insulin resistance and total cholesterol were significantly reduced by high dosage vitamin D supplementation (P<0.05). Total antioxidant capacity and total glutathione levels were significantly elevated as a result of high dosage vitamin D supplementation (P<0.01). In conclusion, high-dose vitamin D supplementation (50,000 IU every 2 weeks) significantly improved insulin resistance in pregnant women with GDM.