Frailty 9X more likely if low vitamin D

Association of low serum 25-hydroxyvitamin D levels with the frailty syndrome in Mexican community-dwelling elderly.

Aging Male. 2015 Nov 10:1-6. [Epub ahead of print]

Gutiérrez-Robledo LM 1, Ávila-Funes JA 2,3, Amieva H 3, Meillon C3, Acosta JL 4,5, Navarrete-Reyes AP 2, Torres-Carrillo N 6, Muñoz-Valle JF 6, Torres-Carrillo NM1, 6.

OBJECTIVE:

Since vitamin D is an important regulator of muscle function, the effect of vitamin D deficiency on frailty syndrome has been recently studied. This cross-sectional study aimed to determine the association between 25(OH)-vitamin D levels and frailty status in Mexican community-dwelling elderly.

METHODS:

Sample of 331 community-dwelling elderly aged 70 or older, a subset of those included in the "Coyoacán cohort" were included. 25(OH)-vitamin D assay and frailty status were measured.

RESULTS:

Mean age was 79.3 years and 54.1% were women. Those classified as frail were more likely to have

• lower Mini-Mental State Examination score (p = 0.015),

• more disability for instrumental activities of daily living (p < 0.001)

• and for activities of daily living (p < 0.001).

Serum 25(OH)-vitamin D levels were lower in the frail subgroup when compared with the non-frail one (p < 0.001). Multivariate logistic regression analyses showed a significant association between intermediate tertile [odds ratios (OR) = 4.13; 95% confidence intervals (CI) 2.00-8.56] or insufficient tertile (OR = 8.95; 95% CI 2.41-33.30) of vitamin D levels and frailty even after adjusting for potential confounders.

CONCLUSION:

These results suggest that older adults with low 25(OH)-vitamin D levels are associated with the probability to being frail compared with those with sufficient vitamin D levels.

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See also VitaminDWik

• Frailty and Vitamin D - many studies

• Overview Seniors and Vitamin D

• Overview Fractures and Falls and Vitamin D

• Seniors 2.2 X more likely to walk slowly if very low vitamin D – meta-analysis Dec 2017

• Vertigo treated by Vitamin D - many studies

• Slow walking speed of youths 14 times more likely if low vitamin D - Dec 2016

• 80 percent of the characteristics of frailty associated with low vitamin D – May 2013

• Vitamin D improves muscle strength, reduces falling, and reduces frailty – review March 2015

• Frailty Call to Action: Vitamin D is one of the action items – June 2013

• Frailty and low muscle mass both associated with low vitamin D – Aug 2013

VitaminDWiki - 10 reasons why seniors have low levels of vitamin D

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