Decidua immunity and Vitamin D – dissertation
Vitamin D in pregnancy: understanding immune effects in the decidua
Tamblyn, Jennifer Ann (2018) , Ph.D. thesis, University of Birmingham.
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1. See also VitaminDWiki
* Miscarriages strongly associated with poor placental, decidua gene which locally activates Vitamin D – Dec 2016
* Recurrent miscarriage associated with half as much vitamin D getting to fetus – Sept 2016
* Both the placenta and decidua, like most tissues, are able to activate vitamin D without the need for a Kidney
* Vitamin D helps women in many ways – review April 2015
* IVF 4X more successful for white women with lots of vitamin D – many studies
* Vitamin D and Human Reproduction – 51 page chapter – April 2017
* Overview Pregnancy and vitamin D
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1. Pregnancy category starts with
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1. Healthy pregnancies need lots of vitamin D has the following summary
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1. See also PubMed
* Vitamin D, the placenta and early pregnancy: effects on trophoblast function Feb 2018
* Ganguly A1, Tamblyn JA1,2,3, Finn-Sell S4, Chan SY5, Westwood M4, Gupta J1,2, Kilby MD1,2, Gross SR6, Hewison M7,3.
* Free PDF online [doi: 10.1530/JOE-17-0491](https://doi.org/10.1530/JOE-17-0491)
* Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D and VDR at the fetal-maternal interface Sep 2017, free PDF online
* Immunological function of vitamin D during human pregnancy Aug 2017 [doi: 10.1111/aji.12716](https://doi.org/10.1111/aji.12716)
Download the PDF from VitaminDWiki
Epidemiology has linked preeclampsia (PET) to vitamin D deficiency. To date, studies have focused upon serum 25-hydroxyvitamin D3 (25(0H. )D3) alone as the marker of vitamin D status.~We provide strong evidence comprehensive analysis of vitamin D metabolites in pregnancy is highly informative, particularly within the context of PET. Uniquely, analysis of maternal urinary metabolites provides a novel insight into vitamin D and the kidney, with lower 25(0H)D3 and 24,25(0H)2D3 excretion early indicators of a predisposition towards PET.
Since vitamin D is a potent regulator of immune function, and the decidua appears a key extra-renal site for vitamin D metabolism, we investigated effects of 1 ,25(0H)2D3 upon decidual uterine natural killer cells and macrophages. We show both express a functional vitamin-D system and demonstrate differential sensitivity to 1 ,25(0H)2D3 compared to their peripheral counterparts.
To understand the functional impact of vitamin D, whole transcriptomic analysis of 1,25(0H)2D3-mediated effects upon uNK and macrophages was performed. We show the actions of vitamin D extend far beyond simple immuno-regulation, targeting major cellular functions including migration, adhesion and apoptosis. In particular, our data support effects highly relevant to decidualisation.
We anticipate these findings to be highly relevant within the context of vitamin D deficiency, mal placentation and PET.
Dissertation includes portions of 5 of her publications
Tamblyn JA, Hewison M, Wagner CL, Bulmer JN, Kilby MD. Immunological role of vitamin D at the maternal-fetal interface. J Endocrinol. 2015; 224(3):R107-21(71). http://dx.doi/org/10.1530/JOE-14-0642
Tamblyn JA, Susarla R, Jenkinson C, Jeffery L, Ohizua O, Chun R, Chan S, Kilby M, Hewison M. Dysregulation of Maternal and Placental Vitamin D Metabolism in Preeclampsia. Placenta 50, 70-77.2016 (104). http://dx.doi/org/10.1016/j.placenta.2016.12.019
Tamblyn J, Jenkinson C, Larner D, Hewison M, Kilby M. Serum and urine vitamin D metabolite analysis in early preeclampsia. Endocr Connect. 2017; pii: EC-17-0308 (105). http://dx.doi/org/10.1530/EC-17-0308
Liu NQ, Larner D, Yao Q, Chun R, Zhou R, Tamblyn JA, Wagner C, Hewison M. Vitamin Ddeficiency and sex-specific dysregulation of placental inflammation. Journal of Steroid Biochemistry and Molecular Biology 2017; S0960-0760(17)30163-2(505). http://dx.doi/org/10.1016/j.jsbmb.2017.06.012
Powell R, Lissauer D, Tamblyn J, Beggs A, Cox P, Moss P, Kilby M. Decidual T cells exhibit a highly differentiated phenotype and demonstrate potential fetal-specificity and a strong transcriptional response to interferon. Journal of Immunology 2017; 199(10):3406-3417 (234) http://dx.doi/org/10.4049/jimmunol.1700114