COPD quality of life improved by 400,000 IU Vitamin D loading dose – RCT

Impact of vitamin D on spirometry findings and quality of life in patients with chronic obstructive pulmonary disease: a randomized, double-blinded, placebo-controlled clinical trial

International Journal of Chronic Obstructive Pulmonary Disease Volume 2019:14 Pages 1495—1501, https://doi.org/10.2147/COPD.S207400

* COPD 2.8 times more likely to be severe if low vitamin D – meta-analysis Oct 2016 * COPD strongly associated with Vitamin D Binding Protein problems – meta-analysis Aug 2015 * COPD severity is associated with Vitamin D deficiency – meta-analyses 2015, 2019 * COPD reduced by 40 percent with monthly 100,000 IU of vitamin D – RCT Jan 2015 * COPD trial to use 80,000 IU of vitamin D weekly – RCT 2021 COPD fought by Vitamin D - many studies has the following {include} {include} AND includes the following sections 50,000 IU weekly - 6X more likely to improve breathing - 2014 50,000 IU helped COPD in many ways - Jan 2015 COPD has become the 3rd largest global cause of disability: ages 50-69 Loading Dose * Overview Loading of vitamin D * Loading may be done as quickly as a single day, to as slowly as 3 months. * It appears that spreading the loading dose over 4-20 days is a good compromise A CAT (COPD Assesment Test) score - from the web (not the one they used)

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COPD Assesment Test improved signifiantly after 2 month loading dose
and doubled that improvement after maintenance dosing of 6 months

Ali Alavi Foumani,1 Mojtaba Mehrdad,1,2 Alireza Jafarinezhad,1 Khadijeh Nokani,3 Alireza Jafari1

• 1 Inflammatory Lung Diseases Research Center, Dept of Internal Medicine, Razi Hospital, School of Medicine, Guilan U. of Medical Sciences, Rasht, Iran;

• 2 Razi Clinical Research Development Center, Guilan University of Medical Sciences, Rasht, Iran;

• 3 Student Research Committee, Department of Internal Medicine, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran

COPD is an irreversible chronic illness with airflow limitation. The aim of the current study was to assess the role of vitamin D3 on quality of life and pulmonary function in patients with COPD. A randomized, double-blinded clinical trial was conducted in 63 patients with COPD. Patients were placed into intervention and placebo groups. Each individual in the intervention group took 50,000 IU vitamin D3 once a week for 8 weeks and then once a month for 4 months. There was no significant difference among FEV1, FEV1/FVC, and number of exacerbations in patients with COPD (P>0.05). In the intervention group, a significant difference was observed in quality of life at 2 months (P<0.001) and 6 months (P<0.001). In addition, qualitative analysis showed that the status of exacerbation had not got worse six months after initiation in the intervention group. The current study shows that consumption of 50,000 IU vitamin D3, as a convenient supplementation in a daily diet, is able to increase quality of life in patients with COPD.