CAD patients with low vitamin D were 1.6 X more likely to die – 27th meta-analysis

Predictive value of 25-hydroxyvitamin D level in patients with coronary artery disease: A meta-analysis

Front Nutr. 2022 Aug 10;9:984487. doi: 10.3389/fnut.2022.984487

Hailing Zhang 1 , Pei Wang 2 , Yu Jie 2 , Yimeng Sun 2 , Xiaoyan Wang 1 , Yu Fan 2

Background: A consensus has not been made about the predictive value of blood vitamin D level in patients with coronary artery disease (CAD). This meta-analysis aimed to assess the association between blood 25-hydroxyvitamin D level and adverse outcomes in patients with CAD.

Methods: Two independent authors searched the articles indexed in PubMed and Embase databases until June 28, 2022. Cohort studies or post-hoc analysis randomized trials evaluating the value of 25-hydroxyvitamin D level in predicting cardiovascular or all-cause mortality, and major adverse cardiovascular events ([MACEs] including

• Death,

• non-fatal myocardial infarction,

• heart failure,

• revascularization,

• stroke, etc.) were included.

Results: The literature search identified 13 eligible studies for our analysis, including 17,892 patients with CAD. Meta-analysis showed that the pooled adjusted risk ratio (RR) was 1.60 (95% confidence intervals [CI] 1.35-1.89) for all-cause mortality, 1.48 (95% CI 1.28-1.71) for cardiovascular mortality, and 1.33 (95% CI 1.18-1.49) for MACEs. Leave-out one study sensitivity analysis suggested that the predictive values of blood 25-hydroxyvitamin D level were reliable.

Conclusions: Low blood 25-hydroxyvitamin D level is possibly an independent predictor of cardiovascular or all-cause mortality and MACEs in patients with CAD. Baseline 25-hydroxyvitamin D level may provide useful information in CAD patients.

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