Bone Mineral Density increased by Resveratrol (which activates the Vitamin D Receptor) – RCT

Created February 2021

Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial

Journal of Bone and Mineral Research, Vol. 35, No. 11, November 2020, pp 2121–2131 https://doi.org/10.1002/jbmr.4115

Rachel HX Wong Jay Jay Thaung Zaw Cory J Xian Peter RC Howe

Bone Mineral Density increases if both of the following 1. Have adeguate ingredients needed to build bone * (Vitamin D, Vitamin K, Magnesium, Silicon, Boron,Calcium etc) * Reseveraltrol increases the amount of Vitamin D which get to the cells 1. Weight bearing exercise Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012 Search VitaminDWiki for BMD OR "Bone Mineral Density" 3490 results as of Feb 2021 --- 1. VitaminDWiki - Vitamin D Receptor activation can be increased in many ways {include} --- 1. Resveratrol improves health (Vitamin D receptor, etc.) - many studies has the following {include} --- 1. Studies of Bone and Resveratrol are listed here: {category} === 1. Studies of Bone and Vitamin D Receptor are listed here: {category}

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Resveratrol, a naturally occurring polyphenol in red grapes and berries, can act as a phytoestrogen. It has been shown to improve both systemic and cerebral circulatory functions, possibly through activation of endothelial estrogen receptors. in vitro and in vivo studies in rodent models also indicate a bone‐protective role for resveratrol, particularly in ovariectomized rat models that mimic postmenopausal osteoporosis caused by estrogen deficiency. Hypothesizing a circulatory benefit of resveratrol in bone tissue, we investigated whether resveratrol supplementation could improve bone health in postmenopausal women. The Resveratrol for Healthy Aging in Women (RESHAW) trial was a 24‐month randomized, double‐blind, placebo‐controlled, two‐period crossover intervention conducted to evaluate the effects of resveratrol (75 mg twice daily) on cognition, cerebrovascular function, bone health, cardiometabolic markers, and well‐being in postmenopausal women. After 12 months of supplementation with resveratrol versus placebo, there were positive effects on bone density in the lumbar spine (+0.016 ± 0.003 g/cm2) and neck of femur (+0.005 ± 0.002 g/cm2), which were accompanied by a 7.24% reduction in C‐terminal telopeptide type‐1 collagen levels, a bone resorption marker, compared with placebo. The increase in bone mineral density in the femoral neck resulted in an improvement in T‐score (+0.070 ± 0.018) and a reduction in the 10‐year probability of major and hip fracture risk. The magnitude of improvement was higher in women with poor bone health biomarker status. Importantly, the improvement in femoral neck T‐score with resveratrol correlated with improvement in perfusion. Our subanalysis also revealed that the bone‐protective benefit of resveratrol was greater in participants who supplemented with vitamin D plus calcium.

Regular supplementation with 75 mg of resveratrol twice daily has the potential to slow bone loss in the lumbar spine and femoral neck, common fracture sites in postmenopausal women without overt osteoporosis.

Tags: Bone Resveratrol