Bone density improved by monthly 50,000 IU of vitamin D for 6 months – RCT
Effect of vitamin D therapy on bone mineral density in patients with diabetic nephropathy; a randomized, double-blind placebo controlled clinical trial
Journal of Diabetes & Metabolic Disorders (2021) https://doi.org/10.1007/s40200-021-00737-y
Gayani Liyanage, Sarath Lekamwasam, Thilak Weerarathna & Chandrani Liyanage
Purpose
Diabetes compromises bone strength resulting increased risk of osteoporosis. Objective of this study was to determine the effect of vitamin D given to patients with early diabetic renal disease on BMD and BMC.
Methods
Patients with diabetic nephropathy were recruited. Treatment group received 50,000 IU of vitamin D3 intramuscularly and the control group was given an equal volume of distilled water (0.25 mL) monthly for six months. Baseline BMD, BMC in the total body, lumbar spine and proximal femur were measured by DXA. After six months measurements were repeated. When trial period was over, a randomly selected subgroup of patients (25 from each group) was followed up for further six-months and measurements were repeated.
Results
Selected patients were randomly assigned to two groups. After six months, the treatment group total body BMD, total body BMC and BMDs of spine, femoral neck and total hip regions increased by 2.0%, 2.2%, 1.8%, 2.1% and 2.6% (P < 0.05 for all within-group differences), respectively. In the Control group, BMD or BMC of any region mentioned above did not change significantly during the initial 6 months (P < 0.05 for the between-groups differences). After 6 months of stopping treatment, a statistically significant reduction of total BMD and BMC was observed in the treatment group (P = 0.009).
Conclusion
This study showed that treatment with high dose vitamin D significantly influences total body BMC, total body BMD, BMDs of spine, femoral neck and hip among patients with diabetic nephropathy.
Each of the following have been found to increase bone mineral density
Enough of a good form of vitamin D for 6+ months (this study)
Additonal vitamins and minerals which help grow bones (Magnesium, Calcium,silicon, etc)
Stress on bones(exercise) to tell the body to increase the bone strength
Note: Bone Strength is a much better indicator of Bone Mineral Density, but is rarely available
Poor guts need different forms of vitamin D
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Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012
Vitamin D monotherapy for just 3 months did not improve bone turnover – Oct 2012
Hypothesis: increased bone mineral density needs protein, Ca, Mg, Vitamin D and K
Osteoporosis treatment with denosumab is helped by Vitamin D and Calcium – 2017
Bone - Health category contains:
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