Benefits of Vitamin D often limited by genes

Vitamin D (Cholecalciferol in blood, fat, breast milk)

Processing by Liver into 'Calcidiol is limited by

               CYP24A1 gene

Outside of the liver Calcidiol' production is limited by

           CYP2R1 gene

Measured Vit D = Calcidiol

                the following genes are invisible to vit D test

Only a portion of Calcidiol is bio-available

           the rest is tied up by Vit D Binding Protein = GC

Kidney excreting = Calcidiol

           is a function of CYP24A1 gene

Active Vit D (from Kidney etc.) = Calcitriol

Vitamin D availability in the cells

           is a function of Vit D receptor gene

It seems that ~30% of the people do not get full benefit from Vitamin D due to gene limitations

It seems that 20% of limitations due to genes are invisible to Vitamin D blood tests

Genetics has the following charts

Vitamin D blood test misses a lot

Click on chart for details

See also VitaminDWiki

• Vitamin D Binding Protein category listing has items along with related searches

• Genetics category listing has items along with related searches

• Health problems that run in families are often associated with low vitamin D

• Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015

• Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014

• Gene differences can result in 14 ng difference in vitamin D levels– Feb 2014

• Common Vitamin D gene variants and resulting diseases – Jan 2013

• 2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015

• Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015

• Hip Fracture 2.5 times more likely if poor Vitamin D Binding Protein gene - Aug 2015

• Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015

• 2 Genes make AMD 6X more likely if low vitamin D - Aug 2015

• Alzheimer’s Disease is associated with genes which restrict vitamin D – Aug 2015

Vitamin D Receptor category has the following

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