8 genes associated with both Alzheimer’s and lowish Vitamin D

Created March 2019

Profiling of Alzheimer’s disease related genes in mild to moderate vitamin D hypovitaminosis

The Journal of Nutritional Biochemistry. Vol 67, May 2019, Pages 123-137, https://doi.org/10.1016/j.jnutbio.2019.01.015

Note: this study did not apparently consider genes which reduce vitamin D getting to tissues * Lower vitamin D in blood causes Alzheimer's Disease (Mendelian gene analysis) – Dec 2019 1. Overview Alzheimer's-Cognition and Vitamin D starts with {include} Items in both categories Cognitive and Genetics are listed here: {category} Items in both categories Cognitive and VitaminD Receptor are listed here: {category}

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A vast majority of the elderly population shows a mild to moderate vitamin D deficiency. Besides the well-known function of vitamin D, vitamin D receptor is also expressed in brain and is discussed to regulate several genes. However very little is known whether genes are regulated, associated with Alzheimer’s disease (AD). Here we investigate 117 genes, known to be affected in AD, in mouse brain samples with a mild vitamin D hypovitaminosis comparable to the vitamin D status of the elderly population (20%–30% deficiency). The 117 genes include two positive controls, Nep and Park7, already known to be affected by both AD and vitamin D hypovitaminosis. The 25 most promising candidates were verified in a second independent mouse cohort, resulting in eleven genes further evaluated against three additional housekeeping genes.

Three of the remaining eight significantly altered genes are involved in APP homeostasis

  • Snca,

  • Nep,

  • Psmb5),

and each one gene in

  • oxidative stress (Park7),

  • Inflammation (Casp4),

  • lipid metabolism (Abca1),

  • signal transduction (Gnb5) and

  • neurogenesis (Plat).

Our results tighten the link of vitamin D and AD and underline that vitamin D influences several genes also in brain, highlighting that a strong link not only to AD but also to other neurodegenerative diseases might exist.

Tags: Cognitive Genetics