4.4 X INCREASE in other respiratory infections in children with influenza vaccinations – RCT
Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine
Randomized Controlled Trial Clin Infect Dis. 2012 Jun;54(12):1778-83. doi: 10.1093/cid/cis307
Benjamin J Cowling 1, Vicky J Fang, Hiroshi Nishiura, Kwok-Hung Chan, Sophia Ng, Dennis K M Ip, Susan S Chiu, Gabriel M Leung, J S Malik Peiris
We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.
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