Loading...
 
Translate Register Log In Login with facebookLogin and Register

Higher vitamin D levels associated with fewer vein clots decades later– Jan 2013

25-hydroxyvitamin D concentrations and risk of venous thromboembolism in the general population with 18,791 participants.

Brøndum-Jacobsen P, Benn M, Tybjaerg-Hansen A, Nordestgaard BG.
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark; The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Denmark; The Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Image
BACKGROUND:
Vitamin D has potential antithrombotic effects suggesting that vitamin D analogs could be used as adjunctive antithrombotic agents. However, epidemiological evidence of an association between reduced 25-hydroxyvitamin D concentrations and risk of venous thromboembolism is lacking.

OBJECTIVES:
We tested the hypothesis that reduced plasma 25-hydroxyvitamin D concentrations associate with increased risk of venous thromboembolism in the general population.

METHODS:
We prospectively studied 18,791 participants from the Copenhagen City Heart Study and the Copenhagen General Population Study. During up to 30 years of follow-up, 950 participants were diagnosed with venous thromboembolism. Plasma 25-hydroxyvitamin D concentrations were adjusted for seasonal variation.

RESULTS:
Cumulative incidence of venous thromboembolism as a function of age increased with decreasing tertiles of seasonally adjusted plasma 25-hydroxyvitamin D (log-rank trend:p= 4×10(-4) ). Comparing participants in the lowest versus the highest tertile of plasma 25-hydroxyvitamin D concentrations, the crude risk estimates in an age and sex adjusted model was a 37% (95% confidence interval: 15%-64%) increased risk of venous thromboembolism. Corresponding risk increases in an age, sex, body mass index, smoking, and cancer adjusted model was 26% (5%-51%), and in a multivariable adjusted model further including physical activity, hormone replacement therapy, menopausal status, oral contraception use, and lipid lowering therapy 28% (6%-53%). Furthermore, corresponding risk increases with attempts to correct for regression dilution bias were 103% (37%-202%), 70%(14%-155%), and 73%(15%-160%) in the three models, respectively.

CONCLUSION:
In these large general population studies, we observed stepwise increasing risk of venous thromboembolism with decreasing tertiles of seasonally adjusted plasma 25-hydroxyvitamin D concentrations.

© 2012 International Society on Thrombosis and Haemostasis.
PMID: 23279309
 Download the PDF from VitaminDWiki


See also VitaminDWiki

See also web

Attached files

ID Name Comment Uploaded Size Downloads
5749 Blood clot.jpg admin 05 Aug, 2015 18:43 25.72 Kb 767
5748 1f4418954186c13f0f38fcdad0c5e0b2a947cdc7bf76a9b78c05edcc410ec760.pdf PDF 2013 admin 05 Aug, 2015 18:42 276.33 Kb 322
See any problem with this page? Report it (FINALLY WORKS)