Higher vitamin D levels associated with fewer vein clots decades later– Jan 2013

25-hydroxyvitamin D concentrations and risk of venous thromboembolism in the general population with 18,791 participants.

Brøndum-Jacobsen P, Benn M, Tybjaerg-Hansen A, Nordestgaard BG.
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark; The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Denmark; The Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

BACKGROUND:
Vitamin D has potential antithrombotic effects suggesting that vitamin D analogs could be used as adjunctive antithrombotic agents. However, epidemiological evidence of an association between reduced 25-hydroxyvitamin D concentrations and risk of venous thromboembolism is lacking.

OBJECTIVES:
We tested the hypothesis that reduced plasma 25-hydroxyvitamin D concentrations associate with increased risk of venous thromboembolism in the general population.

METHODS:
We prospectively studied 18,791 participants from the Copenhagen City Heart Study and the Copenhagen General Population Study. During up to 30 years of follow-up, 950 participants were diagnosed with venous thromboembolism. Plasma 25-hydroxyvitamin D concentrations were adjusted for seasonal variation.

RESULTS:
Cumulative incidence of venous thromboembolism as a function of age increased with decreasing tertiles of seasonally adjusted plasma 25-hydroxyvitamin D (log-rank trend:p= 4×10(-4) ). Comparing participants in the lowest versus the highest tertile of plasma 25-hydroxyvitamin D concentrations, the crude risk estimates in an age and sex adjusted model was a 37% (95% confidence interval: 15%-64%) increased risk of venous thromboembolism. Corresponding risk increases in an age, sex, body mass index, smoking, and cancer adjusted model was 26% (5%-51%), and in a multivariable adjusted model further including physical activity, hormone replacement therapy, menopausal status, oral contraception use, and lipid lowering therapy 28% (6%-53%). Furthermore, corresponding risk increases with attempts to correct for regression dilution bias were 103% (37%-202%), 70%(14%-155%), and 73%(15%-160%) in the three models, respectively.

CONCLUSION:
In these large general population studies, we observed stepwise increasing risk of venous thromboembolism with decreasing tertiles of seasonally adjusted plasma 25-hydroxyvitamin D concentrations.

© 2012 International Society on Thrombosis and Haemostasis.
PMID: 23279309
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See also VitaminDWiki

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See also web

• Higher rates of venous thromboembolism for Black-Americans are likely due to lower serum 25-hydroxyvitamin D levelsDr. Grant Nov 2010
• Does an active sun exposure habit lower the risk of venous thrombotic events? A D-lightful hypothesis. April 2009
• Does vitamin D prevent formation of blood clots? Vitamin D Council blog on this study
• Blood Clot Prevention Is Higher Priority at Hospitals
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