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Diabetic glycation control is inversely related to Vitamin D in India – Feb 2015

Does vitamin D play a significant role in type 2 diabetes?

BMC Endocr Disord. 2015 Feb 26;15(1):5. doi: 10.1186/s12902-015-0003-8.
Sheth JJ1, Shah A2, Sheth FJ3, Trivedi S4, Lele M5, Shah N6, Thakor P7, Vaidya R8.

VitaminDWiki Summary

94% of the participants has < 20 ng of vitamin D
Glycation control inverse relationship in the other 6% (> 20 ng)
See also VitaminDWiki
Overview Diabetes and vitamin D
Why India's vitamin D deficiency is grim - 40 pages Feb 2014
80 percent of young adults had low vitamin D tests in Mumbai India - 2011

Diabetes leads to many diseases - need to restore the vitamin D levels
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Diabetes <==> Depression
Pages listed in BOTH the categories Diabetes and Dark Skin

 Download the PDF from VitaminDWiki

BACKGROUND:
Vitamin D deficiency reportedly is associated with type 2 diabetes (T2DM). We aim to examine whether 25-hydroxyvitamin D (25OHD) has clinically significant influence on hemoglobin glycation (HbA1c) and insulin resistance (HOMA-IR) in T2DM subjects.

METHODS:
Present study was carried out in 912 subjects (429 T2DM cases and 483 non-diabetic controls) from Western India. The enrolled study subjects were investigated for biochemical parameters like FBS, PPBS, HbA1c, FI, HOMA-IR and 25OHD levels in blood.

RESULTS:
Vitamin D deficiency was seen in 91.4% and 93.0% of T2DM cases and control subjects respectively. There was no association of serum 25OHD deficiency on HbA1c or HOMA-IR in T2DM cases (p = 0.057 & p = 0.257 respectively) and in control subjects (p = 0.675 & p = 0.647 respectively).

CONCLUSION:
Our findings suggests that though vitamin D deficiency is prevalent in T2DM and non-diabetic subjects, its role in hemoglobin glycation and insulin resistance could not be established.

PMID: 25887335

Glycation control

Image
B. Relationship between vitamin D non-deficient T2DM cases and HbA1c.
D. Relationship between vitamin D non-deficient Controls and HbA1c.

Clipped from PDF

. . . “low serum vitamin D levels in 70% to 100% populations across India.”
“This is likely to be due to

  • increased skin pigmentation,
  • low exposure to direct sunlight,
  • obesity and malabsorption”

Attached files

ID Name Comment Uploaded Size Downloads
5371 Diabetes India.pdf PDF 2015 admin 22 Apr, 2015 12:02 1.16 Mb 559
5370 Diabetics India.jpg admin 22 Apr, 2015 12:01 36.58 Kb 2473
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