Translate Register Log In Login with facebookLogin and Register

Air pollution while pregnant reduced vitamin D level in infant – Aug 2012

The Journal of Clinical Endocrinology & Metabolism August 17, 2012 jc.2012-1943
Nour Baïz, Patricia Dargent-Molina, John D. Wark, Jean-Claude Souberbielle, Rémy Slama, Isabella Annesi-Maesano and the EDEN Mother-Child Cohort Study Group
Institut National de la Santé et de la Recherche Médicale (INSERM) Epidemiology of Allergic and Respiratory Diseases Department (N.B., I.A.-M.), Unité Mixte de Recherche (UMR)-S707, Paris, France; Medical School Saint-Antoine (N.B., I.A.-M.), Université Pierre et Marie Curie (UPMC), Université Paris 6 (Univ6), F-75571 Paris, France; INSERM Epidemiological Research in Perinatal Health and Women's and Child Health (P.D.-M.), UMR-S953, Villejuif, France; University Pierre and Marie Curie (P.D.-M.), UMR-S953, F-75005 Paris, France; Department of Medicine (J.D.W.), The Royal Melbourne Hospital, The University of Melbourne, Parkville, 3050 Victoria, Australia; Laboratoire de Physiologie (J.-C.S.), Université Paris-Descartes, Hôpital Necker-Enfants-Malades, Assistance Publique Hôpitaux de Paris, Paris, France; INSERM Unité 823 (R.S.), Team “Environmental Epidemiology applied to Reproduction and Respiratory Health,” Institut Albert Bonniot, F-38706 Grenoble, France; and Université J. Fourier Grenoble (R.S.), F-38041 Grenoble, France
Address all correspondence and requests for reprints to: Nour Baïz, Epidemiology of Allergic and Respiratory Diseases Unité Mixte de Recherche-S 707 Institut National de la Santé et de la Recherche Médicale and Université Pierre et Marie Curie (UPMC) Paris 6, Medical School Saint-Antoine, 27 Rue Chaligny 75571 Paris Cedex 12, France. E-mail: baiz at u707.jussieu.fr.

Context: Vitamin D deficiency has been implicated in the increased risk of several diseases.
Exposure to air pollution has been suggested as a contributor to vitamin D deficiency.
However, studies that have examined the effects of air pollution on vitamin D status are few and have never focused on prenatal life as an exposure window.

Objective: Our aim was to investigate the associations between gestational exposure to urban air pollutants and 25-hydroxyvitamin D [25(OH)D] cord blood serum level in 375 mother-child pairs of the EDEN birth cohort.

Design: The Atmospheric Dispersion Modelling System (ADMS-Urban) pollution model, a validated dispersion model combining data on traffic conditions, topography, meteorology, and background pollution, was used to assess the concentrations of two major urban pollutants, particulate matter less than 10 ?m in diameter (PM10) and nitrogen dioxide (NO2), at the mother's home address during pregnancy. Cord blood samples were collected at birth and were analyzed for levels of 25(OH)D.

Results: Maternal exposure to ambient urban levels of NO2 and PM10 during the whole pregnancy was a strong predictor of low vitamin D status in newborns. After adjustment, log-transformed 25(OH)D decreased by 0.15 U (P = 0.05) and 0.41 U (P = 0.04) for a 10-?g/m3 increase in NO2 and PM10 pregnancy levels, respectively. The association was strongest for third-trimester exposures (P = 0.0003 and P = 0.004 for NO2 and PM10, respectively).

Conclusion: Gestational exposure to ambient urban air pollution, especially during late pregnancy, may contribute to lower vitamin D levels in offspring.
This could affect the child's risk of developing diseases later in life.

Received April 11, 2012; Accepted July 31, 2012; Copyright © 2012 by The Endocrine Society
– – – – – – – – –

Possible reasons: by VitaminDWiki

  1. Mother got outdoors less during pollution
  2. Pollution reduced UVB

See also VitaminDWiki


Far less vitamin D in cities with pollution

See any problem with this page? Report it (FINALLY WORKS)