EBioMed - Lancet - DOI: https://doi.org/10.1016/j.ebiom.2018.11.060
D. Enkhmaa, L. Tanz, D. Ganmaa, Sh. Enkhtur, B. Oyun-Erdene, J. Stuart, G. Chen, A. Carr, E.W. Seely, G. Fitzmaurice, Yo. Buyandelger, B. Sarantsetseg, G. Gantsetseg, J. Rich-Edwards
88% of the women got >80% of the vitamin D
Many other studies have found far higher compliance
with weekly or bi-weekly doses instead of daily
Note: Very low levels to start with: 91% < 20 ng
Pregnancy category starts with
- see also
- Overview Pregnancy and vitamin D
- Number of articles in both categories of Pregnancy and:
25 ; Depression 19 ; Diabetes 40 ; Obesity 12 ; Hypertension 36 ; Breathing 30 ; Omega-3 33 ; Vitamin D Receptor 20
- All items in category Infant/Child
- breastfed OR breastfeeding 1920 items as of Dec 2020
- Preeclampsia in VitaminDWiki title (47 as of July 2021)
- Pre-term 368 items (not in PDF) as of Nov 2020
- "polycystic ovary syndrome" OR PCOS 303 items as of Jan 2018
- Gestational Diabetes
- c-section OR "caesarean section" (various spellings) 937 items as of Aug 2020
- postpartum depression 208 items as of Aug 2018
- Search VitaminDiiki for MISCARRIAGE OR "Spontaneous abortion" 794 as of Feb 2020
- Search VitaminDWiki for "Assisted reproduction" 33 items as of Feb 2017
- Fertility and Sperm category listing has
116 items along with related searches
- (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
The trial on this page started a Vitamin D maintenance dose at 12-16 weeks.
Far far better to fully restore the Vitamin D at 2 weeks,
or start maintenace dose before conception
Healthy pregnancies need lots of vitamin D has the following summaryProblem
Reduces Evidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limits
RCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT
RCT = Randomized Controlled Trial
Background: In winter in Mongolia, 80% of adults have 25-hydroxyvitamin D (25(OH)D) concentrations <25 nmol/l (<10 ng/ml) and 99% have <50 nmol/l (<20 ng/ml). The vitamin D dose to avert deficiency during pregnancy in this population is unknown.
We conducted a randomized, controlled, double-blind trial of daily 600, 2000, or 4000 IU vitamin D3 for pregnant women in Mongolia (Clinicaltrials.gov #NCT02395081). We examined 25(OH)D concentrations at baseline (12–16 weeks' gestation), 36–40 weeks' gestation and in umbilical cord blood, using enzyme linked fluorescent assay. Sample size was determined to detect 0.4 standard deviation differences in 25(OH)D concentrations with 80% power.
119 pregnant women were assigned 600 IU, 121 assigned 2000 IU and 120 assigned 4000 IU from February 2015 through December 2016. Eighty-eight percent of participants took ≥80% of assigned supplements. At baseline, 25(OH)D concentrations were similar across arms; overall mean ± standard deviation concentration was 19 ± 22 nmol/l; 91% were < 50 nmol/l.
At 36–40 weeks, 25(OH)D concentrations increased to 46 ± 21, 70 ± 23, and 81 ± 29 nmol/l for women assigned 600, 2000, and 4000 IU, respectively (p < 0.0001 across arms; p = 0.002 for 2000 vs. 4000 IU). Mean umbilical cord 25(OH)D concentrations differed by study arm (p < 0.0001 across arms; p < 0.0001 for 2000 vs. 4000 IU) and were proportional to maternal concentrations. There were no adverse events, including hypercalcemia, attributable to vitamin D supplementation.
Daily supplementation of 4000 IU during pregnancy is safe and achieved higher maternal and neonatal 25(OH)D concentrations than 2000 IU. Daily 600 IU supplements are insufficient to prevent vitamin D deficiency in Mongolia.4,000 IU Vitamin D daily during pregnancy (Mongolia) was good – RCT Dec 2018
1376 visitors, last modified 23 Oct, 2019,This page is in the following categories (# of items in each category)Pregnancy 777
- All items in category Infant/Child