Vitamin D increases Glutathione (a great antioxidant) which fights COVID

Glutathione is a great antioxident
Vitamin D is one way to increase glutathione

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Asked Perplexity May 2024

Which health problems are fought by Glutathione?

19 references

Glutathione, a powerful antioxidant found in every cell of the body, is involved in various health benefits and is used to combat a range of health problems. Here are the key health issues that glutathione helps address:

• Oxidative Stress: Glutathione reduces oxidative stress by counteracting free radicals and other reactive oxygen species, which can lead to cellular damage and contribute to the development of diseases like diabetes, cancer, and rheumatoid arthritis 3.
• Liver Disease: It plays a crucial role in reducing cell damage in alcoholic and nonalcoholic fatty liver disease by improving liver function markers and detoxifying harmful substances 3.
• Cancer: Glutathione is involved in slowing cancer progression and protecting cells from damage that could lead to cancer. It is also used to mitigate the side effects of chemotherapy by reducing the toxicity without diminishing the efficacy of the treatment 1 3.
• Heart Disease: By improving antioxidant defenses, glutathione may help manage heart disease, particularly in reducing symptoms like endothelial dysfunction, which affects blood vessel function 11.
• Neurodegenerative Diseases: Glutathione has shown potential in reducing symptoms of Parkinson's disease and other neurodegenerative disorders by protecting nerve cells from oxidative stress and supporting mitochondrial function 3 6.
• Respiratory Diseases: It is used to treat conditions like cystic fibrosis and other lung diseases by reducing oxidative stress and improving lung function 3 11.
• Immune System Support: Glutathione boosts the immune system by enhancing the function of lymphocytes and reducing inflammation, which is crucial in fighting infections and autoimmune diseases 3 18.
• Aging and Chronic Conditions: By reducing oxidative damage, glutathione can help slow the aging process and manage chronic conditions associated with aging, such as Alzheimer's disease and osteoarthritis 3 11.
• Autism: Some studies suggest that glutathione levels are lower in children with autism, and supplementing with glutathione could potentially improve antioxidant defenses in these children 3.
• Inflammatory Diseases: Glutathione helps manage inflammation in diseases like ulcerative colitis and could be beneficial in other inflammatory conditions due to its antioxidant properties 3.
• Detoxification: It aids in detoxifying heavy metals, drugs, and other environmental toxins, supporting liver health and preventing toxic overload 12 13.

These diverse roles highlight glutathione's importance in maintaining health and managing various diseases, primarily through its capacity to reduce oxidative stress and support detoxification processes.

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What are the relationships between Glutathione and "vitamin d"?

Glutathione and vitamin D have an important bidirectional relationship:

1. Higher glutathione levels are associated with higher vitamin D levels. Several studies have found a positive correlation between blood levels of glutathione and vitamin D [25(OH)D]. As glutathione levels increase, vitamin D levels also tend to increase.
2. Glutathione is necessary for the activation and bioavailability of vitamin D. Adequate glutathione status in the liver upregulates the vitamin D regulatory genes, allowing vitamin D to be activated. Insufficient glutathione impairs these genes, preventing proper vitamin D activation.
3. Correcting vitamin D deficiency can increase glutathione levels. Studies have shown that when vitamin D deficiency is corrected, either through supplementation or sun exposure, glutathione levels in the body also increase.
4. Supplementing with both vitamin D and glutathione precursors like N-acetylcysteine (NAC) or L-cysteine is more effective than vitamin D alone for raising vitamin D levels. The glutathione precursors help boost glutathione status, which then allows better vitamin D activation and bioavailability.

In summary, glutathione and vitamin D have a synergistic relationship where higher levels of one support higher levels of the other. Maintaining adequate levels of both is important for overall health.
References

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Glutathione pathway.com considers Vitamin D the best way to increase glutathione

http://glutathionepathway.com/health-benefits-vitamin-d/

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Glutathione disease cure.com considers Vitamin D the best way to increase glutathione

http://www.glutathionediseasecure.com/vitamin-d-facts.html

• Researchers in France found that vitamin D increases GSH levels in the brain and seems to be a catalyst for GSH production.”
• “ The amount of vitamin D in the brain was proportional to sun exposure or the amount of supplementation taken.”
• “"New clues about vitamin D functions in the nervous system". Trends in Endocrinology and Metabolism 13 (3): 100–5. 2002”

__Benefits of Vitamin D3 Exposed by glutathione pro.com--

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Wikipedia: 5 ways to increase Glutathione

• N-acetylcysteine
• alpha lipoic acid
• Vitamin D
• SAMe

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9 Ways to Boost Glutathione Dr. Axe

• “. . . Coined “The Mother of All Antioxidants” by Mark Hyman, MD”
• “Pronounced “gloota-thigh-own,” nearly 117,000 peer-reviewed scientific articles have addressed this powerhouse molecule”
  “ Deals with Pre-mature aging, Infections, Chronic stress, Injuries, Environmental toxins, . . .
• ““If you look in a hospital situation at people who have cancer, AIDS, or other very serious disease, almost invariably they are depleted in glutathione. The reasons for this are not completely understood, but we do know that glutathione is extremely important for maintaining intracellular health.””

1 Milk Thistle
2. Whey Protein
3. Sulfur Foods
4. NAC
5. α-Lipoic Acid
6. Methylation Nutrients (Vitamins B6, B9, B12, and biotin)
7. Selenium
8. Vitamin C & E
9. Beef Liver
   Note: vitamin D is not mentioned

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How To Raise Glutathione Levels

Many ways, including many of the above, vitamin D not mentioned

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Glutathione: Meet the master antioxidant for optimal health - May 2024

maturalHealth365

• "A small protein molecule, glutathione, is synthesized in the body from three different amino acids: L-cysteine, L-glutamic acid, and glycine. Although it exists in every cell, the vast majority of glutathione is in the liver."
• "Unfortunately, glutathione levels begin to fall at midlife and can plummet as low as only 50 percent of what the body needs for optimal health. In addition to aging, low glutathione can also result from overconsumption of heavily processed foods, environmental toxins, drugs, illness, infections, and stress."
• "Other conditions linked to glutathione deficiency (beyond heart attack, cancer) include:
  • autoimmune diseases,
  • chronic fatigue syndrome,
  • diabetes,
  • Alzheimer’s disease,
  • Parkinson’s disease,
  • autism,
  • arthritis,
  • kidney failure, and
  • liver disease – to name just a few."

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Searched Pubmed for Glutathione "vitamin d" 449 items as of April 2024

• The role of high dose vitamin d and glutathione supplementation in COVID-19 treatment: A case series - Feb 2023 DOI: 10.3855/jidc.17109
  • 10 patients in Indonesia,received a high dose of vitamin D and glutathione supplementation daily.
  • Within 5-7 days of treatment, all patients were confirmed COVID-19 negative.  PDF
• L-cysteine supplementation upregulates glutathione (GSH) and vitamin D binding protein (VDBP) in hepatocytes cultured in high glucose and in vivo in liver, and increases blood levels of GSH, VDBP, and 25-hydroxy-vitamin D in Zucker diabetic fatty rats - April 2016
   Download the PDF from VitaminDWiki
• Metabolome alterations in severe critical illness and vitamin D status – July 2017
  “CONCLUSION: Vitamin D status is associated with differential metabolic profiles during critical illness. Glutathione and glutamate pathway metabolism, which play principal roles in redox regulation and immunomodulation, respectively, were significantly altered with vitamin D status.”
   Download the PDF from VitaminDWiki
• Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes. – July 2013,Free PDF online
• Vitamin D status is independently associated with plasma glutathione and cysteine thiol/disulphide redox status in adults. – Sept 2014, Free PDF online
• Vitamin D deficiency is associated with an oxidized plasma cysteine redox potential in critically Ill children. – Jan 2018, Free PDF online
• Vitamin D status is independently associated with plasma glutathione and cysteine thiol/disulphide redox status in adults – April 2014

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Why take glutathione and vitamin C together? June 2020

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The Ultimate Crash Course on Glutathione! video - April 2024

51 minute YouTube
have not looked at it

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Unlocking Glutathione Your Body’s Super Antioxidant with Dr. Patel - May 2024

YouTube - 85 minutes
have not looked at it

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VitaminDWiki - Glutathione and Vitamin D synergism - many studies

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3 of the 90 studies with Glutathione and COVID in title - Google Scholar as of April 2024

Google Scholar

• The role of Glutathione as an adjunct therapy in the treatment of patients with COVID-19-Related Acute Respiratory Syndrome - Jan 2022 FREE PDF
  • 10 patients in Indonesia,received a high dose of vitamin D and glutathione supplementation daily.
  • Within 5-7 days of treatment, all patients were confirmed COVID-19 negative.
• The Role of Glutathione in Prevention of COVID-19 Immunothrombosis: A Review - March 2023 FREE PDF
• The role of high dose vitamin d and glutathione supplementation in COVID-19 treatment: A case series - Feb 2023 FREE PDF

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VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos

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