Vitamin D Deficiency: An Underestimated Factor in Sepsis?
Int. J. Mol. Sci. 2023, 24(3), 2924; https://doi.org/10.3390/ijms24032924
by Charlotte Delrue 1,Reinhart Speeckaert 2,Joris R. Delanghe 3 and Marijn M. Speeckaert 1,4, Belgium
Vitamin D is an important immune modulator that is linked to infection susceptibility. It has been suggested that vitamin D deficiency plays a role in sepsis and septic shock because vitamin-D-related pathways are associated with various immunological, endocrine, and endothelial functions. Previous research has yielded inconclusive results regarding the link between mortality and vitamin D deficiency in sepsis patients. In patients with sepsis and severe vitamin D deficiency, an adequate vitamin D concentration may reduce mortality. Randomized controlled trials to assess the influence of vitamin D supplementation on clinical outcomes in sepsis patients with vitamin D deficiency are uncommon. We will provide an overview of the current knowledge about the relationship between vitamin D and sepsis in this review, as well as consider the potential value of vitamin D supplementation in this situation.
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VitaminDwiki - Sepsis is both prevented and treated by Vitamin D - many studies contains
- Sepsis is more likely in those with poor immune systems
Infants, the elderly, the sick, and those with low vitamin D - Severe sepsis has been associated with low Vitamin D and poor Vitamin D receptor in many studies
- Loading doses of Vitamin D bypass any poor Vitamin D Receptors
- Vitamin D loading doses have been proven to treat sepsis (RCTs: 2015, 2020, 2021)
Reduced: ICU stay by 8 days, Hospital stay by 7 days, and readmission rate reduced to 0%
Note: The fastest way (2 hours) to have a sublingual loading dose of Vitamin D nano-emulsion - Sepsis is fought by Vitamin D in 9 ways – Feb 2023