Recommend 100 IU of vitamin D per kg of infant - Poland July 2011

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Vitamin d supplementation and status in infants: a prospective cohort observational study.

J Pediatr Gastroenterol Nutr. 2011 Jul;53(1):93-9.
Pludowski P, Socha P, Karczmarewicz E, Zagorecka E, Lukaszkiewicz J, Stolarczyk A, Piotrowska-Jastrzebska J, Kryskiewicz E, Lorenc RS, Socha J.
Department of Biochemistry and Experimental Medicine, Poland
Department of Gastroenterology, Hepatology and Immunology, Children's Memorial Health Institute, Aleja Dzieci Polskich, Poland
Department of Biochemistry and Clinical Chemistry, Warsaw Medical University, Banacha Warsaw, Poland
Department of Pediatrics and Auxiology, "Dr. L.Zamenhof" University Children's Hospital, Medical University of Bialystok, ul. Waszyngtona, Bialystok, Poland.

OBJECTIVE: Vitamin D status in infants depends on supplementation. We examined the vitamin D status in relation to supplementation dose and scheme in infants.

PATIENTS AND METHODS: One hundred thirty-four infants age 6 months and 98 infants age 12 months (drop out 27%) were investigated. Vitamin D intake (diet, supplements), anthropometry, and 25-hydroxyvitamin D (25-OHD) serum concentration at the 6th and 12th months were assessed.

RESULTS:Vitamin D intake of 1062 ± 694 IU at the 6th month was not different from that at the 12th month (937 ± 618 IU). Vitamin D intake expressed in international units per kilogram of body weight decreased from 141 ± 80 IU/kg at the 6th month to 93 ± 62 IU/kg at the 12th month (P < 0.0001), which was associated with a reduction in 25-OHD from 43 ± 20 ng/mL to 29 ± 12 ng/mL, respectively (P < 0.0001).

In the subgroup of everyday supplemented infants (n = 43), vitamin D intake decreased from 143 ± 88 IU/kg at the 6th month to 118 ± 60 IU/kg at the 12th month (P < 0.05), which coincided with a reduction of 25-OHD from 40 ± 19 ng/mL to 32 ± 13 ng/mL (P < 0.01).

In the subgroup with variable supplementation habits (n = 32), vitamin D intake decreased from 146 ± 79 IU/kg to 77 ± 56 IU/kg (P < 0.001), which was associated with a reduction of 25-OHD from 42 ± 21 ng/mL to 25 ± 8 ng/mL (P < 0.0001). 25-OHD concentration change between the 6th and the 12th months negatively correlated with the 25-OHD level assessed at the 6th month (r = -0.82; P < 0.0001).

CONCLUSIONS: Vitamin D supplementation of infants should consider their rapid body weight increment.
We postulate vitamin D daily dose close to 100 IU/kg body weight as favorable for infants up to age 12 months.
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NOTES

• 1000 IU per 25 lbs (recommended by some in the US) is about 1% different than 100 IU/kg
• The Red line is the average weight of children at that age.
• This article recommends this amount up to age 12 months, others recommend it for up to age 12 years
• Many Veterinary recommend this amount for cows, horses, etc. (file, not web page)

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See also VitaminDWiki - Veterinary

• Overview Veterinary and vitamin D
  Based on: what actually works, what is cost effective, and what does not have ANY side-affects
• Category Veterinary and D 151 items
• Primate Nutrient Requirements – 2003 US Govt
  (Note: Primates must have D3, not D2: are humans not primates?)
• Swine need sunshine or 500-2800 IU vitamin D3

See also VitaminDWiki

• Category Europe and Vitamin D 165 items
• Vitamin D Recommendations from around the world]
• Overview Moms babies and vitamin D
• Conference on Vitamin D in Poland - Oct 2012
• Autism in children reduced by Vitamin D (used 300 IU per kg per day) – RCT Oct 2016
• Infants receiving 1600 IU of vitamin D were safe and healthy – Aug 2012

Fewer than 40% of infants get 400 IU of vitamin D,

• A June 2010 study - MANY children do not even get 200 IU, and NONE of the children got more than 480 IU

• Intervention of 400 IU of vitamin D raised infant blood levels 14 ng – Jan 2012
• French Society of Paediatics Vitamin D recommendations – Jan 2012 breastfed infants: 1000 to 1200 IU
• Breastfed infants in Germany with 250 IU of vitamin D got to 56ng – Sept 2010
• One study gave infants 50,000 IU very two months (833/day)
• Most mothers still do not supplement infants with vitamin D – July 2010
• 400 IU vitamin D daily was enough for most infants – Jan 2011
• Only about 10 % of breastfed infants get even the minimum recommended vitamin D – April 2010
• Infants getting 1400 IU vitamin D weekly grew better – May 2011
• Infants in Finland need 1600 IU of vitamin D – RCT Aug 2012
• Absurdity of 600 IU vitamin D for 10 lb infant or 300 lb adult - Mar 2011
  has image of a 270 lb man in diapers