Prostate problem (BPH) reduced by herbs, Zinc, Vitamin D etc.

How the herbs help - Nov 2014

How the herbs help - Nov 2014

The Pharmacological Effects of Natural Products and Herbs in Benign Prostatic Hyperplasia
Austin J Nutri Food Sci. 2014;2(10): 1054. full free text on-line
Summary: The pharmacological effects of plant extracts in the treatment of BPH.

Name	Main mechanisms of action
Saw Palmetto extraction	5α-reductase inhibition; blockage androgen receptors; anti-proliferation; anti-inflammatory activity; prostate smooth muscle relaxation;
Lycopene (tomatoe)	5α-reductase inhibition;; anti-proliferation; anti-inflammatory; anti-oxidant activity
Urtica dioica extract (Stinging nettel root	WEAK 5α-reductase inhibition; Decreased action of sex hormones;
Pygeum africanum extract	5α-reductase inhibition;; anti-inflammatory activity

Summary figure

One company states that the ripest berries provide the most benefit

Saw Palmetto (been used for 2000+ years)

Note: One company states that the ripest berries provide the most benefit

JAMA - 1998: similar to finastreride, with fewer adverse events

Saw Palmetto Extracts for Treatment of Benign Prostatic Hyperplasia: A Systematic Review
"However, the evidence suggests that S repens improves urologic symptoms and flow measures. Compared with finasteride, S repens produces similar improvement in urinary tract symptoms and urinary flow and was associated with fewer adverse treatment events. "

Zdravniški Vestnik - 2014: efficacy 70%

Efficacy and safety of drug with plant extract of saw palmetto in patients with lower urinary tract symptoms because of benign prostatic enlargement
12 months 320 mg (Prostasan), IPSS (International Prostate Symptom Score) score reduced from 14 to 11
"patients and doctors rated the efficacy of drug as good (69.7% and 72.4%) "

Pharmacy & Pharmacology International Journal - Dec 2014: appears to be effective

Saw Palmetto, Serenoa repens, in the Treatment of Benign Prostatic Hyperplasia, Mechanisms of Action and Reasons for its Use
"Metaanalyses and systematic reviews of the trials have concluded that S. repens appears to be effective in the treatment of benign prostatic hyperplasia. "
Link includes full free text

Video review of BPH supplements (some do not contain as much as claimed - Sept 2024

YouTube 27 minutes
00:00 Introduction
00:49 BPH (Benign prostatic hyperplasia)
01:52 Symptoms
04:10 Why does BPH occur?
09:41 How to reduce our risk
13:45 Supplements
15:41 Stinging mettle
22:06 Side effects
26:16 Takeaway

Examine.com unsure

Saw palmetto has undergone numerous trials and meta-analyses for BPH, with mixed results.

Pygeum (been used by whites for 300+ years)

Europe 1998 multicenter trial

Efficacy and Acceptability of Tadenan®(Pygeum africanum Extract) in the Treatment of Benign Prostatic Hyperplasia (BPH): A Multicentre Trial in Central Europe
2 months of 50 mg twice a day
Initially nocturia was 2.6 times per night. ==>1.8 per night (32% reduction)
Initially International Prostate Symptom Score was 16. ==> 9.6 (40% reduction)
Researchers were surprised to find that many of the benefits lasted for one month after supplementation was stopped.
Publisher wants $52 for the study

Examine.com -~20% reduction

http://examine.com/supplements/Pygeum
Urinary complications with Benign prostatic hyperplasia appear to be reduced with Pygeum supplementation in the range of 19-23% (including nocturia, residual urine volume,. . .
The bark of Pygeum tends to contain . . β-sitosterol (349-583mg/kg)
Also has a discussion on 2002 Cochrane meta-analysis of Pygeum

Beta Sitosterol (an active ingredient of Pygeum)

Life Extension Foundation - 2005

Report: Beta-Sitosterol
full free text online

Summary of Random Controlled Trials

Cochrane - July 1999 It works

Beta-sitosterols for benign prostatic hyperplasia
"The review found that beta-sitosterol treatments were well tolerated and improved urinary symptoms and flow measures in men with mild to moderate BPH." full free text for patients, otherwise the publisher charges for the study

A REVIEW ON PUMPKIN SEEDS IN PROMOTING PROSTATE HEALTH - 2022

Download the PDF from VitaminDWiki

Perhaps Vitamin K2 (already taking it)

Hypothesis: Vitamin K will reduce prostate blood vessel problems – Jan 2015

Benign prostate hyperplasia and nutrition (zinc and Vitamin D, and supplements like Saw palmetto, etc) 2019

https://doi.org/10.1016/j.clnesp.2019.07.015 FREE PDF

Age-Related Changes in Zinc, Copper and Selenium Levels in the Human Prostate - April 2021

https://doi.org/10.3390/nu13051403 FREE PDF

Zinc to shrink your prostate

The #1 Important Nutrient to Shrink Your Prostate Dr. Berg 9 minute video
Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders Aug 2020 https://doi.org/10.3389/fonc.2020.01293 FREE PDF
Does Zinc Work for Treating Prostatitis? - 2020 FREE TEXT
Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders = Aug 2020 DOI: 10.3389/fonc.2020.0129 PDF

Zinc in Prostate Health and Disease: A Mini Review - Dec 2022

Biomedicines 2022, 10(12), 3206; https://doi.org/10.3390/biomedicines10123206
by Nishi Karunasinghe
Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, U. of Auckland, Private Bag 92019, Auckland 1142, New Zealand

Introduction-With the high global prevalence of prostate cancer and associated mortalities, it is important to enhance current clinical practices for better prostate cancer outcomes. The current review is towards understanding the value of Zn towards this mission. Method-General information on Zn in biology and multiple aspects of Zn involvement in prostate health and disease were referred to in PubMed.

Results-The most influential feature of Zn towards prostate health is its ability to retain sufficient citrate levels for a healthy prostate. Zn deficiencies were recorded in serum, hair, and prostate tissue of men with prostate cancer compared to non-cancer controls. Zn gut absorption, albumin binding, and storage compete with various factors. There are multiple associations of Zn cellular influx and efflux transporters, Zn finger proteins, matrix metalloproteinases, and Zn signaling with prostate cancer outcomes. Such Zn marker variations associated with prostate cancer recorded from biological matrices may improve algorithms for prostate cancer screening, prognosis, and management when coupled with standard clinical practices.

Discussion-The influence of Zn in prostatic health and disease is multidimensional, therefore more personalized Zn requirements may be beneficial. Several opportunities exist to utilize and improve understanding of Zn associations with prostate health and disease.
Click here to find PDF