High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery.
J Bone Miner Metab. 2011 Mar 8.
Shibata M, Suzuki A, Sekiya T, Sekiguchi S, Asano S, Udagawa Y, Itoh M.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Serum 25-hydroxyvitamin D (25-OHD) concentrations are thought to accurately reflect vitamin D stores, and vitamin D deficiency causes secondary hyperparathyroidism, irreversible bone loss, and increased risk of fracture.
Recent studies suggest that decrease of serum 25-OHD level in mothers could increase the risk of preeclampsia, cesarean section, and craniotabes.
Furthermore, this deficiency may affect bone mass and the incidence of neuromuscular diseases of their children in the future.
In the present study, the serum concentration of 25-OHD in 93 pregnant women after the 30th week of their gestation was determined by direct radioimmunoassay. Mean 25-OHD levels in spring, summer, fall, and winter were 14.3 ± 5.1, 15.7 ± 6.4, 13.7 ± 5.1, and 13.9 ± 4.2 ng/ml, respectively.
Severe vitamin D deficiency (25-OHD < 10 ng/ml) was found in 10 of these 93 women. Overall, hypovitaminosis D, which was defined as serum 25-OHD concentration equal to or less than 20 ng/ml, was revealed in 85 mothers (89.5%).
Serum 25-OHD levels were not associated with either intact parathyroid hormone or corrected calcium concentrations, but were negatively associated with serum type I collagen N-terminal telopeptide and bone-specific alkaline phosphatase in these subjects. Mothers with threatened premature delivery had significantly lower 25-OHD levels (11.2 ± 3.2 ng/ml) than those in mothers with normal delivery (15.6 ± 5.1 ng/ml).
In conclusion, the present data suggest a high prevalence of hypovitaminosis D in perinatal pregnant Japanese women throughout the year, which seems to affect bone metabolism and to be associated with threatened premature delivery.
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- Spring = 14 ng; Summer = 16 ng; Fall = 14 ng; Winter = 14 ng
- 90% < 20 ng/ml
- premature 11 ng vs normal 16 ng
See also VitaminDWiki
- Preemies have increased need for vitamin D and Calcium (Rickets)– May 2013
- Overview Moms babies and vitamin D Vitamin D: Before, During, and After Pregnancy
- Arab pre-term infants often have less than 10 ng of vitamin D - 2010
- Vitamin D and Obstetrics Improving Pregnancy and Childbirth - presentations May 2011
- Why vitamin D reduces premature birth - April 2011
- Premature delivery associated with low vitamin D in Japanese women – Mar 2011
- 7X more likely to have low birth weight babies when mother very low on vitamin D – March 2010