Pneumonia 2.6X more likely if low vitamin D – April 2013

Serum 25-hydroxyvitamin D3 and the risk of pneumonia in an ageing general population

J Epidemiol Community Health doi:10.1136/jech-2012-202027
Alex Aregbesola, alex.aregbesola@uef.fi
Sari Voutilainen,
Tarja Nurmi,
Jyrki K Virtanen,
Kimmo Ronkainen,
Tomi-Pekka Tuomainen
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, North Savo, Finland
Received 5 October 2012; Revised 15 February 2013; Accepted 21 March 2013; Published Online First 17 April 2013

Background Vitamin D has been suggested to have a role in infection defence and on the immune system. We therefore investigated the effect of serum 25-hydroxyvitamin D3 (25(OH)D3) on the risk of incident hospitalised pneumonia in an ageing general population in eastern Finland.

Methods The study population included 723 men and 698 women aged 53–73  years from the prospective population-based Kuopio Ischemic Heart Disease Risk Factor study who were free of pneumonia, other pulmonary diseases and cancer at baseline in 1998–2001. Incident pneumonia episodes leading to hospitalisation were collected by record linkage to the hospital discharge register. The serum vitamin D status was assayed as 25(OH)D3 concentration. Cox proportional hazards regression models were used to analyse the effect of serum 25(OH)D3 on the risk of incident pneumonia.

Results The mean (SD) serum 25(OH)D3 concentration of the study population was 43.5 (17.8)  nmol/l. 73 subjects had at least one hospitalisation episode due to pneumonia during an average follow-up of 9.8  years.
After multivariable adjustments, the subjects in the lowest serum 25(OH)D3 tertile had a 2.6-fold (95% CI 1.4 to 5.0, p trend across tertiles=0.005) higher risk of developing pneumonia compared with the subjects in the highest tertile. This significant result remained even after adjustment for the determinants of serum 25-hydroxyvitamin D3.

Conclusions These data suggest an inverse effect of serum 25(OH)D3 concentration on the risk of incident pneumonia in the general ageing population.

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See also VitaminDWiki

• Pneumonia and low vitamin D - many studies
• Pneumonia acquired in hospital – 3X more likely to die if low vitamin D – June 2015
• ICU patients with pneumonia stay 7 days longer if low vitamin D - Dec 2011
• Vitamin D Pneumonia and COPD - thesis 105 pages 2010 file
• All items in Breathing and vitamin D category 452 items
• Pneumonia in seniors was 2.5X more likely if low vitamin D – June 2014 later study, very similar conclusion
• Pulmonary disease and vitamin D – Mar 2011

Graph shows a 40% chance of wheezing at age 80 if have less than 10 nanograms of vitamin D

Pneumonia review by Vitamin D Council May 2014