Vitamin D and Liver Cancer Risk: A Meta-Analysis of Prospective Studies
Asia Pac J Clin Nutr, 29 (1), 175-182 2020, DOI: 10.6133/apjcn.202003_29(1).0023
Xiao-Fei Guo 1, Ting Zhao 2, Jian-Min Han 1, Shan Li 1, Duo Li 3 4
Liver Cancer 3X more likely if low Vitamin D – Feb 2019
Items in both categories Liver Cancer and Meta-analysis:
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- 3X less risk of Liver cancer if more than 30 ng of vitamin D – meta-analysis July 2020
- Liver Cancer 8 percent less likely for every 4 ng higher level of vitamin D – Meta-analysis April 2020
- Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019
Background and objectives: The association between circulating vitamin D and liver cancer risk has been controversial on the basis of epidemiological studies. The aim of this study was to quantitatively evaluate this association with prospective studies.
Methods and study design: A systematic literature search was implemented in PubMed and Scopus databases up to June 2019. Using a random-effects model, the multivariate-adjusted relative risks (RRs) with corresponding 95% confidence interval (CI) were pooled for the highest versus lowest category. Trend estimation was conducted with a two-stage dose-response meta-analysis.
Results: Six independent prospective studies (992 liver cancer events and 60,811 participants) were included for data synthesis. The summary estimate showed that a higher circulating vitamin D was associated with lower risk of liver cancer (Summary RR=0.78; 95% CI: 0.63, 0.95; I2=53.6%, p=0.035). Dose-response analysis indicated that liver cancer was associated with 8% (95% CI: 0.89, 0.95) lower risk with a 10 nmol/L increment of circulating vitamin D concentration.
Conclusions: The present study provides substantial evidence that a higher concentration of circulating vitamin D would have conferred protection against liver cancer.