Preoperative Vitamin D Deficiency Is Associated With Higher Postoperative Complication Rates in Total Knee Arthroplasty
Orthopedics. https://doi.org/10.3928/01477447-20180424-04
Vishal Hegde, MD; Armin Arshi, MD; Christopher Wang, BS; Zorica Buser, PhD; Jeffrey C. Wang, MD; Andrew R. Jensen, MD; John S. Adams, MD; Erik N. Zeegen, MD; Nicholas M. Bernthal, MD
This study compared <20 ng with > 20 ng
Anticipate much higher benefit if it had compared < 20ng with > 40 ng
However, they probably did not have enough data
It is far less likely to need a knee replacement if have >40 ng of vitamin D
- Trauma and surgery category listing has
351 items along with related searches - Fewer Complications Following Revision Hip and Knee Arthroplasty in Patients with Normal Vitamin D Levels – March 2017
- Search VitaminDWiki for (Hip OR Knee) Arthroplasty 181 hits as of April 2019
- Total hip replacement: 14 times more likely to redo if low vitamin D – March 2017 - free!
- 4 fewer days in hospital after hip or knee replacement if good level of vitamin D – June 2016
- Surgical outcomes are better for higher levels of Vitamin D – systematic review May 2015
Having enough vitamin D minimizes the need for hip/knee replacement
- Hip fracture 50 percent more likely if low in both vitamin D and vitamin K1 – Dec 2015
- Hip fracture 3X more likely if low vitamin D – Dec 2015
- Knee joint space narrowing (Osteoarthritis) 1.5X worse with low vitamin D – meta-analysis Sept 2015
- Knee pain in seniors predicted by low vitamin D 5 years before – Feb 2014
- Hip fractures reduced 2X to 6X with just 10 minutes of sunlight daily – RCT 2003-2010
The purpose of this study was to determine the relative incidence of postoperative complications in 25-hydroxyvitamin D (25D)-deficient and -sufficient patients undergoing total knee arthroplasty (TKA). Patients who were either serum 25D deficient (25D <20 ng/mL) or 25D sufficient (25D ≥20 ng/mL) 90 days prior to primary TKA from 2007 to 2016 were identified using the Humana administrative claims registry. The incidence of postoperative medical and surgical complications was determined by querying for relevant International Classification of Diseases, Ninth Revision and Current Procedural Terminology codes. Risk-adjusted odds ratios (ORs) were calculated using multivariate logistic regression with age, sex, and Charlson Comorbidity Index as covariates. In total, 868 of 6593 patients who underwent TKA from 2007 to 2016 were 25D deficient, corresponding to a 13.2% prevalence rate.
On adjustment for age, sex, and Charlson Comorbidity Index, 25D-deficient patients had a higher incidence of postoperative- stiffness requiring manipulation under anesthesia (OR, 1.69; 95% confidence interval [CI], 1.39–2.04; P<.001),
- surgical site infection requiring irrigation and debridement (OR, 1.76; 95% CI, 1.25–2.48; P=.001), and
- prosthesis explantation (OR, 2.97; 95% CI, 2.04–4.31; P<.001) at 1 year.
Patients who were 25D deficient also had higher rates of
- postoperative deep venous thrombosis (OR, 1.80; 95% CI, 1.36–2.38; P<.001),
- myocardial infarction (OR, 2.11; 95% CI, 1.41–3.15; P<.001), and
- cerebrovascular accident (OR, 1.73; 95% CI, 1.17–2.57; P=.006).
Thus, serum 25D levels below 20 ng/mL are associated with a higher incidence of postoperative complications and may be a perioperative modifiable risk factor in TKA.
Printer Friendly Follow this page for updates3940 visitors, last modified 02 Apr, 2019,