Hypothesis – Fatigue the day after sex is due to deficiency of Vitamin D, Magnesium, and Zinc

Admin at VitaminDWiki, (as of 2016 - age 70) has not been exhausted after ejaculation.
I found that taking Zinc and Magnesium (ZMA: 30 mg of Zinc, 450 mg of Magnesium Asperatate, 15 mg of vitamin B6) reduced the exhaustion but did not eliminate it.
Added 10,000 IU of vitamin D and D-Ribose: No longer exhausted the next day

Magnesium and vitamin D are very synergistic; that is, increasing one also increases the other.


I could not seem to find good search terms for what I experienced

  • Post Orgasmic Illness Syndrome
  • Sexual Fatigue
  • fatigue day after sex -sleep -sleepy
    but I was able to find some related information on Erectile dysfunction, vitamin D, and magnesium: June 2011

These are very interesting associations, but nothing conclusive

Most of the Wikipedia list of causes of ED is also associated with low vitamin D

  • Drugs (anti-depressants (SSRIs) and nicotine are most common)
  • Neurogenic disorders (spinal cord and brain injuries, nerve disorders such as
    • Parkinson's disease, Alzheimer's disease, multiple sclerosis, and stroke)
  • Cavernosal disorders (Peyronie's disease)
  • Psychological causes: performance anxiety, stress, mental disorders
    clinical depression, schizophrenia, substance abuse, panic disorder, generalized anxiety disorder,
    personality disorders or traits), psychological problems, and negative feelings.
  • Surgery (radiation therapy, surgery of the colon, prostate, bladder, or rectum may damage the nerves and blood vessels involved in erection.
    Prostate and bladder cancer surgery often requires removing tissue and nerves surrounding a tumor, which increases the risk for impotence8)
  • Aging. It is four times higher in men in their 60s than in men in their 40s.
  • Kidney failure
  • Diseases such as diabetes and multiple sclerosis (MS).
    While these two causes have not been proven, they’re likely suspects as they cause issues with both the blood flow and nervous systems.
  • Lifestyle: smoking is a key cause of erectile dysfunction.
    Smoking causes impotence because it promotes arterial narrowing. See also Tobacco and health.

MS and ED

ED is helped by LEVITRA, which contains magnesium stearate

Clips from Dr. Sorenson– 2008

“In 1939, Dr. Abraham Myerson measured initial levels of circulating testosterone in men and exposed their various body parts to UVB light. After five days of chest exposure sufficient to cause reddening, circulating testosterone increased by 120%. After eight days without additional UV exposure, testosterone returned to its initial levels. When the genital area was exposed, testosterone levels increased by 200%!”

“If vitamin D increases fertility, conception rates should be higher in summer than in winter. In higher latitude countries, where UVB availability varies dramatically during the year, conception rates are indeed at their highest in late summer, and birth rates are highest the following spring.
Vitamin D levels are exceptionally low in people with chronic kidney disease, and sufferers generally experience sexual problems, including erectile dysfunction in men, decreased libido and fertility in both sexes and menstrual abnormalities in women. Whether vitamin D is responsible or simply a result of kidney disease is unknown.”

Interventions for treating sexual dysfunction in patients with chronic kidney disease.

Cochrane Database Syst Rev. 2010 Dec 8;(12): CD007747.
Vecchio M, Navaneethan SD, Johnson DW, Lucisano G, Graziano G, Saglimbene V, Ruospo M, Querques M, Jannini EA, Strippoli GF.
Clinical Pharmacology and Epidemiology, Mario Negri Sud Consortium, Via Nazionale 8/A, Santa Maria Imbaro, Chieti, Italy, 66030.

BACKGROUND: Sexual dysfunction is very common in patients with chronic kidney disease (CKD) but is still significantly understudied.
Treatment options exist, but concerns have been raised about their efficacy and safety in CKD.

OBJECTIVES: We assessed the benefits and harms of existing interventions for treating sexual dysfunction in patients with CKD.

SEARCH STRATEGY: In October 2010, we searched the Cochrane Renal Group's specialized register, CENTRAL (The Cochrane Library, issue 10), MEDLINE (from 1966), and EMBASE (from 1980).

SELECTION CRITERIA: Randomised controlled trials (RCTs) and quasi-RCTs of any pharmacological and non-pharmacological interventions used to treat sexual dysfunction in male and female CKD patients (predialysis, dialysis, and kidney transplant) were included.

DATA COLLECTION AND ANALYSIS: Two authors independently selected eligible studies, extracted data, and assessed study quality. Disagreements were resolved in consultation with an arbitrator. Treatment effects were summarised as risk ratios (RR), mean differences (MD), or standardized mean difference (SMD) with 95% confidence intervals (CI) using a random-effects model.

MAIN RESULTS: Fifteen studies (8 parallel, 7 crossovers; 352 patients) were included.
Only one study enrolled women. Studies evaluated the effects of

  • phosphodiesterase-5 inhibitors (PDE5i),
  • zinc,
  • vitamin E,
  • vitamin D or
  • bromocriptine

compared to a placebo. PDE5i significantly increased the overall International Index of Erectile Function-5 (IIEF-5) score (2 studies, 101 patients, MD 10.65, 95% CI 5.34 to 15.96), all its individual domains and the complete 15-item IIEF tool (1 study, 41 patients, MD 2.64, 95% CI 1.32 to 3.96).

End-of-treatment testosterone levels were not significantly increased by the addition of zinc to dialysate (2 studies, 22 patients, MD 0.21 ng/mL, 95% CI -2.14 to 2.55), but oral zinc improved end-of-treatment testosterone levels (1 study, 20 patients, SMD 1.62, 95% CI 0.58 to 2.66).

There was no difference in plasma luteinizing and follicle-stimulating hormone levels at the end of the study period with zinc therapy.

Only sparse data were available for vitamin E, bromocriptine, and dihydroxycholecalciferol in CKD patients, and there were no studies of intracavernous injections, transurethral injections, mechanical devices, or psychosexual therapies in people with CKD.

AUTHORS' CONCLUSIONS: PDE5i and zinc are promising interventions for treating sexual dysfunction in men with CKD. Evidence supporting their routine use in CKD patients is limited. There is an unmet need for studying interventions for both male and female sexual dysfunction in CKD, considering the significant disease burden.
PMID: 21154382
– – – –
Strange – Vitamin D was mentioned in their list the studies, but Vitamin D was not in their results.

On the web

Many risk factors which were listed above are associated with low vitamin D

See also VitaminDWiki

PubMed Search for ("vitamin D" (testosterone OR androgen))
got 1071 items Jan 2016

  • Hypovitaminosis D is associated with erectile dysfunction in type 2 diabetes.
  • Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men.
  • Vitamin D deficiency and fatigue: an unusual presentation. - free PDF
  • Plausible ergogenic effects of vitamin D on athletic performance and recovery. - free PDF
  • Vitamin D supplementation and testosterone concentrations in male human subjects.
  • Serum 25-hydroxyvitamin D levels and testosterone deficiency in middle-aged Korean men: a cross-sectional study.- free PDF
  • Effect of vitamin D supplementation on testosterone levels in men.
  • Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young, healthy men.
  • Serum 25-hydroxyvitamin D concentration and physical function in adult men.

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