Evidence for Vitamin D - Grant Aug 2011

by Dr. William Grant, unpublished work in progress,

for Vitamin D Council as of Aug 2011

PubMed = Aug 8, 2011 PubMed.gov , words in title and/or abstract;
  for cancer, the first number is a search using “vitamin D” and “breast cancer”
  while the second number is a search using “vitamin D”, “breast” and “cancer”
  PM2 = Feb, 2011, not updated in Aug, 2011
E = Ecol = ecological studies
O = Obser = observational studies,
R = RCT = randomized controlled trial (or used in treatment with positive results)
S = Strong Evidence = * = some combination of ecological, observational, cross-sectional studies,
  and/or randomized controlled trials (RCTs) and possibly an understanding of the mechanisms.
  Since solar UVB is the primary source of vitamin D, he does not consider it necessary to have a supporting RCT.
M = Mod = moderate strength evidence
A =Assoc. = associated effects of low vitamin D due to comorbid diseases or treatment.

Disease	PubMed	Ecol	Obser	RCT	Strong	Mod	Weak	Assoc
Acne	15							A
Amyotrophic lateral sclerosis	7						W
Anaphylaxis - food allergy	8	E	O			M
Anemia *	165		O	R	S
Ankylosing spondylitis	22							A
Anxiety	30						W
Asthma {moving toward strong}	134		O	R		M
Atopic dermatitis - eczema	24		O	R		M
Atherosclerosis *	158		O		S
Autism	21	E	O			M
Bacterial vaginosis *	7		O		S
Benign prostate hyperplasia	12		O				W
Biliary cirrhosis - primary (PBC)	101	E				M
Birth defects	6						W
Bronchitis	2
Cancer * - All	2485	E	O	R	S
Cancer -Bladder *	21/43	E			S
Cancer - Brain	0/19	E				M
Cancer - Breast *	540/667	E			S
Cancer - Cervical	9/18	E
Cancer - Colon	228/339
Cancer - Colorectal *	244	E			S
Cancer - Endometrial *	18/29	E			S
Cancer - Esophageal *	6/17	E			S
Cancer - Eye (uveal)	3/8
Cancer - Gallbladder *	2 /8	E			S
Cancer - Gastric *	15/29	E			S
Cancer - Head & neck	5 /21
Cancer - Hodgkin disease *	27 PM2	E			S
Cancer - Leukemia	306	E				M
Cancer - Liver	3 /59
Cancer - Lymphoma	94
Cancer - Lung	56/99	E				M
Cancer - Melanoma	166	E				M
Cancer - Multiple myeloma	61		O				W
Cancer - Non-Hodgkin's lymphoma *	24	E			S
Cancer - Non-melanoma skin	16
Cancer - Ovarian *	60/94	E			S
Cancer - Pancreatic	43/60	E				M
Cancer - Prostate	577/688	E				M
Cancer - Rectal	30/65
Cancer - Renal *	6/121	E			S
Cancer - Vulvar *	0/2	E			S
Cardiac arrhythmia	2
Cardiovascular (disease) *	979		O		S
Celiac disease	86							A
Chronic kidney failure *	627		O		S
Chronic liver disease	51						W	A
Chronic or diffuse muscle pain	20 PM2
Chronic obstructive pulmonary disease	48		O			M
Cognitive impairment	28		O			M
Common cold				R		M
(Congestive) heart failure	141		O			M
Coronary heart disease *	59		O		S
Craniotabes	20
Cystic fibrosis	106		O	R			W
Dementia	66						W
Dental caries *	36	E	O		S
Depression	163		O			M
Diabetes - type 1	196 PM2		O			M
Diabetes - type 2 *	904 PM2		O		S
Diabetes	1006
Epilepsy	100		O				W	A
Fabry disease	3
Falls or fractures (see also Osteo) *	263		O	R	S
Fertility - regular menses	48		O			M		A
Fibromyalgia	23		O	R			W
Gaucher disease	6
Headache - tension	16		O			M
Hepatitis	92
HIV/AIDS	135	E	O	R		M
Hypercalcemia	1205
Hypertension	476	E	O	R		M
IBD or Crohn's or Colitis *	152	E	O		S			A
Influenza *	42	E	O	R	S
Insulin resistance *	185		O	R	S
Kidney stones	44							A
Learning (disorders)	21
Leprosy	18
Lupus	125							A
Meningococcal dis. - meningitis *	4	E			S
Multiple sclerosis *	366		O		S
Muscular weakness	146 PM2		O
Myopathy *	84				S
Myositis	9
Neutropenia	9
Osteitis deformans	0
Osteoarthritis	105						W
Osteomalacia	1198
Osteopenia	678
Osteoporosis *	3448		O	R	S
Paget's bone disease	58		O	R		M
Pancreatitis	39
Parkinson's disease	43		O			M
Pelvic floor status	2
Periodontal disease	64		O			M
Peripheral vascular disease	12		O			M
Pneumonia *	37	E		R	S
Polycystic ovary syndrome *	18		O	R	S
Preeclampsia *	38		O		S
Premature birth & low birth weight	165
Psoriasis - psoriatic arthritis	371			R		M
Renal failure	822
Renal osteodystrophy	344
Respiratory tract infections	18
Rheumatoid arthritis	222		O					A
Rickets *	2155			R	S
Rosacea	6							A
Schizophrenia	73	E				M
Seasonal affective disorder	8
Sepsis/septicemia *	40	E	O		S
Sickle cell disease	20							A
Spinal stenosis	6
Stroke	106		O			M
Systemic sclerosis	15
Thalassaemia	16
Thrombosis	32		O			M
Tonsillitis	2					M
Tuberculosis *	259		O	R	S
Turner syndrome	5
Vitiligo vulgaris	27							None
- - - -		- - - - -	- - - - -	- - - - -	- - - -	- - - - -	- - - -	- - - -

Evidence for Vitamin D - Grant Aug 2011

by Dr. William Grant, unpublished work in progress,

for Vitamin D Council as of Aug 2011

Note: additional evidence for a disease can be added by looking at

See also VitaminDWiki