1,100 IU Vitamin D needed to get most to 20 ng (look at individual not summary data) – April 2018

Vitamin D Requirements for the Future—Lessons Learned and Charting a Path Forward

Nutrients 2018, 10(5), 533; doi:10.3390/nu10050533
Kevin D. Cashman
Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, T12 Y337 Cork, Ireland
Received: 6 April 2018 / Revised: 19 April 2018 / Accepted: 23 April 2018 / Published: 25 April 2018
(This article belongs to the Special Issue Changing Times for Vitamin D and Health)

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Not much varience when look at summaryof trial results
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Huge variance when look at individula data from the trials
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RDA should be >1,100 IU to account for individual differences
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Estimates of dietary requirements for vitamin D or Dietary Reference Values (DRV) are crucial from a public health perspective in providing a framework for prevention of vitamin D deficiency and optimizing vitamin D status of individuals. While these important public health policy instruments were developed with the evidence-base and data available at the time, there are some issues that need to be clarified or considered in future iterations of DRV for vitamin D. This is important as it will allow for more fine-tuned and truer estimates of the dietary requirements for vitamin D and thus provide for more population protection. The present review will overview some of the confusion that has arisen in relation to the application and/or interpretation of the definitions of the Estimated Average Requirement (EAR) and Recommended Dietary Allowance (RDA). It will also highlight some of the clarifications needed and, in particular, how utilization of a new approach in terms of using individual participant-level data (IPD), over and beyond aggregated data, from randomised controlled trials with vitamin D may have a key role in generating these more fine-tuned and truer estimates, which is of importance as we move towards the next iteration of vitamin D DRVs.

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