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Vitamin D reduces respiratory tract infections by 40 percent– meta-analysis Dec 2012

Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis

Journal of Pharmacology and Pharmacotherapeutics , 2012 , Volume 3, Issue 4,Page 300-303
Jaykaran Charan1, Jagdish P Goyal2, Deepak Saxena3, Preeti Yadav1
1 Department of Pharmacology, Govt. Medical College, Rajkot, India
2 Department of Pharmacology, P. D. U. Govt. Medical College, Rajkot, India
3 Department of Epidemiology, Indian Institute of Public Health, Ahmedabad, Gujarat, India
Date of Web Publication 24-Nov-2012
Correspondence Address: Jaykaran Charan, Department of Pharmacology, Govt. Medical College, Surat, Gujarat, India

Objectives : To explore the effect of vitamin D supplementation in prevention of respiratory tract infections on the basis of published clinical trials.

Materials and Methods : Clinical trials were searched from various electronic databases. Five clinical trials were suitable for inclusion. Outcome was events of respiratory tract infections in vitamin D group and placebo group. Data was reported as odds ratio with 95% confidence interval. Both random and fixed model was used for analysis. Analysis was done with the help of Comprehensive meta-analysis software 2.

Results : Events of respiratory tract infections were significantly lower in vitamin D group as compared to control group [Odds ratio = 0.582 (0.417 - 0.812) P = 0.001] according to random model. Results were similar in fixed model. On separate analysis of clinical trials dealing with groups of children and adults, beneficial effect of vitamin D was observed in both, according to fixed model [Odds ratio = 0.579 (0.416 - 0.805), P = 0.001 and Odd ratio = 0.653 (0.472 - 0.9040, P = 0.010 respectively]. On using random model beneficial effect persisted in children's group but became nonsignificant in adults group [Odds ratio = 0.579 (0.416 - 0.805), P = 0.001 and Odd ratio = 0.544 (0.278 - 1.063) P = 0.075 respectively].

Conclusion : Vitamin D supplementation decreases the events related to respiratory tract infections. There is need of more well conducted clinical trials to reach to a certain conclusion.

How to cite this article:
Charan J, Goyal JP, Saxena D, Yadav P. Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis. J Pharmacol Pharmacother 2012;3:300-3

How to cite this URL:
Charan J, Goyal JP, Saxena D, Yadav P. Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis. J Pharmacol Pharmacother [serial online] 2012 [cited 2012 Nov 27];3:300-3. Available http://www.jpharmacol.com/text.asp?2012/3/4/300/103685
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Note that only vitamin D monotherapy was considered, thus ignoring trials using cofactors

Image
PDF is attached at the bottom of this page

See also VitaminDWiki

See also web (another analysis)

Attached files

ID Name Comment Uploaded Size Downloads
1750 Respire Fig 1 PRISMA.jpg admin 27 Nov, 2012 14:26 45.41 Kb 1083
1749 Respiratory tract review Dec 2012.pdf PDF admin 27 Nov, 2012 14:25 698.54 Kb 771
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