J Nephrol. 2012 Mar-Apr;25(2):204-10. doi: 10.5301/JN.2011.8429.
Levin A, Le Barbier M, Er L, Andress D, Sigrist MK, Djurdjev O.
BC Provincial Renal Agency, Vancouver, British Columbia, Canada. alevin at providencehealth.bc.ca
Vitamin D deficiencies are well described in general populations and in those with chronic kidney disease (CKD). Although serum 25(OH)D may be a good indicator of vitamin D status in healthy individuals, the hydroxylated product, 1,25(OH)(2)D, essential for important biological functions such as mineral metabolism, bone turnover, regulation of protein synthesis, cell differentiation and proliferation may be a more suitable indicator for individuals with CKD.
We report an observational prospective cohort study of the incidence after 12 months of new isolated 1,25(OH)(2)D and new 25(OH)D deficiency in CKD patients (estimated glomerular filtration rate eGFR <60 ml/min), who were vitamin D replete at baseline. All analyses were run in a central laboratory.
Of 1,256 patients who completed the study at 12 months, 631 were replete in both 25(OH)D and 1,25(OH)(2)D at baseline; at 12 months, 65% remained replete, 25% developed an isolated 1,25(OH)(2)D deficiency, whereas only 6% developed an isolated 25(OH)D deficiency. Based on the multinomial logistic regression model, factors that were associated with 12-month changes in vitamin D status were diabetes, baseline values of eGFR, albumin and both 25(OH)D and 1,25(OH)(2)D (all p values <0.03). Patients with diabetes, lower albumin, lower eGFR, lower levels of 25(OH)D and 1,25(OH)(2)D at baseline were at increased risk of developing isolated 1,25(OH)(2)D deficiency.
The high incidence of new isolated 1,25(OH)(2)D deficiency as compared with new 25(OH)D deficiency, in the presence of 25(OH)D sufficiency, brings into question the value of measuring 25(OH)D levels in CKD. The significance of these findings and implications for replacement strategies require further study.
- Chronic Kidney Disease reduced with 3500 IU average vitamin D – RCT Aug 2012
- Calcitriol category listing has
54 items along with related searches
- 5700 IU of vitamin D helped half with chronic kidney disease if not having dialysis – July 2012
- 7000 IU daily restored vitamin D levels for those with Chronic Kidney Disease – July 2012
- Overview Kidney and Vitamin D
- Kidney Conference had many Vitamin D papers – May 2012
- Need at least 80 ng of vitamin D if have chronic kidney disease – May 2012
- Adding Vitamin decreased kidney deaths by 4x – Dec 2010
It is amazing that such excellent results were buried in the paper. They were not in the title nor abstract.
This is the result of about 10 trials with about 5,000 kidney disease patients.
Note: some of the trials were terminated as they felt it was morally wrong to not give vitamin D to all of the Kidney patients
- All items in Kidney and Vitamin D
210 itemsWith CKD should measure the active form of vitamin D – April 2012 5370 visitors, last modified 26 Jul, 2015,This page is in the following categories (# of items in each category)