Serum Vitamin D Deficiency as a Predictor of Incident Non-Alzheimer Dementias: A 7-Year Longitudinal Study.
Dement Geriatr Cogn Disord. 2012 Jan 19;32(4):273-278.
Annweiler C, Rolland Y, Schott AM, Blain H, Vellas B, Beauchet O.
Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers University Memory Center, UPRES EA 2646, University of Angers, UNAM, Angers, France.
Background: Hypovitaminosis D has been cross-sectionally associated with dementia and stroke. The objective of this longitudinal study was to determine whether serum vitamin D deficiency at baseline could predict the onset of non-Alzheimer dementias (NAD) within 7 years among older women.
Methods: Forty high-functioning older women (78.4 years, 76.4/82.0; median, 25th/75th percentile) from the EPIDOS Toulouse study were divided into two groups based on vitamin D deficiency (i.e., serum 25-hydroxyvitamin D <10 ng/ml) at baseline.
At the end of the 7-year follow-up period, women matching the DSM-IV but not the NINCDS-ADRDA criteria were diagnosed with NAD while those matching the NINCDS-ADRDA criteria were considered to have Alzheimer's disease (AD).
Subtle cognitive impairments at baseline, cardiovascular risk factors and Parkinson's disease were used as potential confounders.
Results: NAD was reported in 6 women (82.8 years, 80.6/86.0) after 7 years of follow-up.
More NAD were observed in women with vitamin D deficiency (p = 0.023).
There was no between-group difference regarding the onset of AD (p = 0.332).
We found an association between vitamin D deficiency at baseline and the onset of NAD (adjusted odds ratio = 19.57, p = 0.042).
Conversely, vitamin D deficiency was not associated with AD (p = 0.222).
Conclusion: Baseline vitamin D deficiency predicted the onset of NAD within 7 years among older women.
Copyright © 2012 S. Karger AG, Basel.
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