Serum 25-Hydroxyvitamin D Level as an Independent Determinant of Quality of Life in Osteoporosis With a High Risk for Fracture☆
Hiroaki Ohta, MD, PhD, Yukari Uemura, PhD, Toshitaka Nakamura, MD, PhD, Masao Fukunaga, MD, PhD, Yasuo Ohashi, PhD, Takayuki Hosoi, MD, PhD, Satoshi Mori, MD, PhD, Toshitsugu Sugimoto, MD, PhD, Eiji Itoi, MD, PhD, Hajime Orimo, MD, PhD, Masataka Shiraki, MD, PhDemail address, for the Adequate Treatment of Osteoporosis (A-TOP) Research Group
Background: Deteriorated quality of life (QOL) is a major problem in osteoporotic women. However, little is known regarding the determinants of QOL in patients with osteoporosis.
Objective: Our aim was to explore the role of vitamin D status on QOL score in osteoporosis with high fracture risk.
Patients were osteoporotic women aged ≥70 years and with ≥1 risk factor for incident fracture, namely prevalent osteoporotic fracture, bone mineral density (BMD) >–3.0 SD of young adult mean, or high bone turnover marker. Health-related QOL was assessed using the Japanese Osteoporosis Quality of Life Questionnaire (JOQOL). When patients were classified into quartiles by total QOL score). Serum 25-hydroxyvitamin D (25OHD) level was measured by immunoassay.
A total of 1585 osteoporotic women were included in the study (age range, 70–95 years). Age, body mass index, serum 25(OH)D status (low, normal, or high), bone mineral density, number of prevalent vertebral fractures, presence of hypertension, presence of osteoarthritis, and history of falls were significantly correlated with QOL quartile. Multivariate liner regression analysis indicated that low serum 25(OH)D level (<20 ng/mL) was an independent determinant of total QOL score quartile (P = 0.0055).
The conventional determinants of
- QOL—age (P < 0.0001),
- body mass index (P = 0.0060),
- number of prevalent vertebral fractures (P < 0.0001),
- presence of osteoarthritis (P = 0.0074), and
- history of fall (P = 0.0098)
- were also independent determinants of total QOL score.
These results strongly suggest that low serum 25(OH)D level was a significant determinant of QOL in these osteoporotic women, independently of the conventional factors that reduce QOL. Maintenance of serum 25(OH)D levels >20 ng/mL may be required to maintain patients’ QOL in osteoporosis.
- Quality of Life category listing has
Overview Osteoporosis and vitamin D contains the following summary
- FACT: Bones need Calcium (this has been known for a very long time)
- FACT: Vitamin D improves Calcium bioavailability (3X ?)
- FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
- FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
- FACT: Vitamin D supplements are very low cost
- FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
- FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
- FACT: Co-factors help build bones.
- FACT: Vitamin D Receptor can restrict Vitamin D from getting to many tissues, such as bones
- It appears that to TREAT Osteoporosis:
- Calcium OR vitamin D is ok
- Calcium + vitamin D is good
- Calcium + vitamin D + other co-factors is great
- Low-cost Vitamin D Receptor activators sometimes may be helpful
- CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
- Category Osteoporosis has
- Category Bone Health has
Note: Osteoporosis causes bones to become fragile and prone to fracture
Osteoarthritis is a disease where damage occurs to the joints at the end of the bonesOsteoporosis quality of life better if more than 20 ng of vitamin D – Jan 2014
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- Category Bone Health has