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More postpartum infections if low vitamin D (in winter) - Dec 2019

Vitamin D deficiency at the time of delivery – Prevalence and risk of postpartum infections

PLOS x https://doi.org/10.1371/journal.pone.0226673
Daniel Axelsson, Jan Brynhildsen, Marie Blomberg

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Histogram of total infections across all levels of vitamin D
(this is not % of infections @ each level of vitamin D)

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% with < 20 ng of vitamin D at time of birth

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Background
Postpartum infections are a common cause of morbidity after childbirth. Vitamin D deficiency has been shown to increase the risk for several infections in a non-pregnant population. Vitamin D deficiency has been described as common in pregnant women.

Objective
To investigate whether vitamin D deficiency in pregnant women in labor was associated with an increased risk of overall postpartum infectious morbidity within eight weeks of delivery. A secondary aim was to estimate the prevalence of vitamin D deficiency among pregnant women in Linköping, Sweden at the time of delivery.

Material and methods
Serum vitamin D levels in labor were analyzed for 1397 women. Vitamin D deficiency was defined as serum levels <50 nmol/L. All ICD-10 codes given to the women eight weeks postpartum were reviewed and postpartum infections were defined as the presence of an ICD-10 code suggestive of infection. The prevalence of postpartum infections among women with sufficient vitamin D levels was compared with women with vitamin D deficiency. Adjusted Odds Ratios and 95% confidence intervals for postpartum infections were calculated using multivariate logistic regression analysis.

Results
Fifty eight per cent of the women had serum vitamin D levels <50 nmol/L. The proportion of women with vitamin D deficiency varied, as expected, with season. No association between vitamin D deficiency and postpartum infections was found. For vitamin D 25–50 nmol/L the adjusted Odds Ratio was 0.85 (95% confidence interval 0.56–1.29) and for vitamin D <25 nmol/L the adjusted Odds Ratio was 1.15 (95% confidence interval 0.66–2.03). Women who smoked or who had a cesarean section had an increased risk of postpartum infections.

Conclusions
Vitamin D deficiency was more common than previously reported in Swedish pregnant women. No association between vitamin D deficiency and postpartum infections was found. Other well-known risk factors for postpartum infection were identified.


Created by admin. Last Modification: Friday December 20, 2019 00:02:30 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
13194 Deficiency vs month.jpg admin 19 Dec, 2019 50.32 Kb 418
13193 Infection.jpg admin 19 Dec, 2019 27.14 Kb 414
13192 postpartum infections.pdf admin 19 Dec, 2019 1.09 Mb 466