Monthly high-dose vitamin D3 supplementation and self-reported adverse events in a 4-year randomized controlled trial
Clinical Nutrition, DOI: https://doi.org/10.1016/j.clnu.2018.07.034
Zarintaj Malihi, Carlene M.M. Lawes, Zhenqiang Wu, Ying Huang, Debbie Waayer, L. Toop, Kay-Tee Khaw, Carlos A. Camargo Jr., Robert Scragg : r.scragg at auckland.ac.nz
- One pill every two weeks gives you all the vitamin D most adults need
- Vitamin D update – 40-60 ng ideal, 50K biweekly maintenance – Jan 2014
- Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT May 2018
- 100,000 IU of vitamin D monthly decreases use of NASIDs by 13 percent if low vitamin D – RCT May 2018
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169 items in category Intervention - non daily
1 or 2 per month may be BETTER than daily
- 50,000 IU of vitamin D every two weeks – Jordan conclusion - RCT July 2017
- 50,000 every two weeks is slightly better than 100,000 once a month
- Vitamin D every 25 days may be BETTER than daily – RCT May 2018
- Monthly vitamin D dosing had higher response than 3 per month – RCT Jan 2018
Take vitamin D3 daily or weekly has the following
- Notional chart for Vitamin D supplementation for levels < 30 nanograms
- Notional chart of Vitamin D benefit vs dosing frequency for > 50 nanograms
PDF is available free at Sci-Hub 10.1016/j.clnu.2018.07.034
Background: The use of high-dose vitamin D supplementation has increased in recent years. However, relatively little is known about the safety of long-term high doses.
Aims: To investigate the safety of a monthly high-dose of vitamin D3 supplementation taken for up to 4 years.
Data were collected in a randomized, double blind, placebo-controlled trial of 5108 adults aged 50–84 years old from Auckland, New Zealand. Participants were given monthly doses of 100,000 IU vitamin D3 or placebo, for a median of 3.3 years (range 2.5–4.2 years). They answered an open-ended question in a monthly questionnaire about any adverse events they attributed to the study capsules, which were coded blindly. Incidence rates per person months were calculated for categories of adverse events. Cox regression model used to calculate hazard ratio of time to first adverse-event.
In total, 419 (16.5%) participants taking vitamin D and 399 (15.8%) taking placebo reported ≥1 adverse event. Compared to placebo, the hazard ratio (HR) of reporting first adverse event in the vitamin D group was 1.03 (95% CI: 0.90, 1.18; p = 0.63). Despite a slightly higher incidence of recurrent adverse events in vitamin D arm, the incidence rate ratio (1.17) was not significantly higher in vitamin D (95% CI: 0.97, 1.41; p = 0.10). All regression results were adjusted for age, sex, and ethnicity. There was no difference between study arms in terms of participants’ allocation perception (p = 0.52).
Monthly supplementation of 100,000 IU vitamin D3 for a median of 3.3 years did not affect participant-reported adverse events.
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- 50,000 IU of vitamin D every two weeks – Jordan conclusion - RCT July 2017