The Journal of Nutritional Biochemistry. Available online 21 June 2014
Julie Marcotorchinoa, b, c, Franck Tourniairea, b, c, Julien Astiera, b, c, Esma Karkenia, b, c, Matthias Canaulta, b, c, Marie-Josèphe Amiota, b, c, David Bendahanc, d, Monique Bernardc, d, Jean-Charles Martina, b, c, Benoit Giannesinic, d, Jean-François Landriera, b, c, jean-francois.landrier at univ-amu.fr
Prospective studies reported an inverse correlation between 25 hydroxy-vitamin D plasma levels and prevalence of obesity and type 2 diabetes. In addition, 25 hydroxy-vitamin D status may be a determinant of obesity onset. However, the causality between these observations is not yet established. We studied the preventive effect of vitamin D3 supplementation (15000 IU/kg of food for 10 weeks) on onset of obesity in a diet-induced obesity mouse model.
We showed that the vitamin D3 supplementation limited weight gain induced by high-fat diet, which paralleled with an improvement of glucose homeostasis. The limitation of weight gain could further be explained by an increased of lipid oxidation, possibly due to an up-regulation of genes involved in fatty acid oxidation and mitochondrial metabolism, leading to increased energy expenditure.
Altogether, these data show that vitamin D3 regulates energy expenditure, and suggest that vitamin D3 supplementation may represent a strategy of preventive nutrition to fight the onset of obesity and associated metabolic disorders.
Grants: This work was funded by INRA and Aix-Marseille University.
Copyright © 2014 Published by Elsevier Inc. $35.95
How much Vitamin D would this be for a human
It appears that the average human adult consumes 4 lbs of food per day
We assume the same amount of food consumed per body weight for humans and mice.
Then we can compute the vitamin D daily dose equivalent for a human
15,000 *4 / 2.5 = 24,000 IU/day
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- FACT: People who are obese have less vitamin D in their blood
- FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
- FACT: When obese people lose weight the vitamin D level in their blood increases
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- FACT: 153 trials for vitamin D intervention of obesity as of Sept 2020
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- FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
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- OBSERVATION: Many mammals had evolved to add fat and vitamin D in the autumn
- and lose both in the Spring - unfortunately humans have forgotten to lose the fat in the Spring
- SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc.
- Obesity category has
Less weight gain in mice getting lots of vitamin D – June 2014
- Vitamin D Council review of this study behind a $5/month paywall
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