The Journal of Nutritional Biochemistry. Available online 21 June 2014
Julie Marcotorchinoa, b, c, Franck Tourniairea, b, c, Julien Astiera, b, c, Esma Karkenia, b, c, Matthias Canaulta, b, c, Marie-Josèphe Amiota, b, c, David Bendahanc, d, Monique Bernardc, d, Jean-Charles Martina, b, c, Benoit Giannesinic, d, Jean-François Landriera, b, c, jean-francois.landrier at univ-amu.fr
Prospective studies reported an inverse correlation between 25 hydroxy-vitamin D plasma levels and prevalence of obesity and type 2 diabetes. In addition, 25 hydroxy-vitamin D status may be a determinant of obesity onset. However, the causality between these observations is not yet established. We studied the preventive effect of vitamin D3 supplementation (15000 IU/kg of food for 10 weeks) on onset of obesity in a diet-induced obesity mouse model.
We showed that the vitamin D3 supplementation limited weight gain induced by high-fat diet, which paralleled with an improvement of glucose homeostasis. The limitation of weight gain could further be explained by an increased of lipid oxidation, possibly due to an up-regulation of genes involved in fatty acid oxidation and mitochondrial metabolism, leading to increased energy expenditure.
Altogether, these data show that vitamin D3 regulates energy expenditure, and suggest that vitamin D3 supplementation may represent a strategy of preventive nutrition to fight the onset of obesity and associated metabolic disorders.
Grants: This work was funded by INRA and Aix-Marseille University.
Copyright © 2014 Published by Elsevier Inc. $35.95
How much Vitamin D would this be for a human
It appears that the average human adult consumes 4 lbs of food per day
We assume the same amount of food consumed per body weight for humans and mice.
Then we can compute the vitamin D daily dose equivalent for a human
15,000 *4 / 2.5 = 24,000 IU/day
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- Vitamin D Council review of this study behind a $5/month paywall
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