Vitamin D status and outcomes in heart failure patients.
Eur J Heart Fail. 2011 May 4.
Liu LC, Voors AA, van Veldhuisen DJ, van der Veer E, Belonje AM, Szymanski MK, Silljé HH, van Gilst WH, Jaarsma T, de Boer RA.
Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB Groningen, The Netherlands.
Vitamin D status has been implicated in the pathophysiology of heart failure (HF). The aims of this study were to determine whether a low vitamin D status is associated with prognosis in HF and whether activation of the renin-angiotensin system (RAS) and inflammatory markers could explain this potential association.
METHODS AND RESULTS:
We measured 25-hydroxy-vitamin D (25(OH)D), plasma renin activity (PRA), interleukin-6 (IL-6), C-reactive protein (CRP), and the incidence of death or HF rehospitalization in 548 patients with HF. Median age was 74 (64-80) years, left ventricular ejection fraction was 30% (23-42), and mean follow-up was 18 months.
Low 25(OH)D levels were associated with
- female gender (P< 0.001),
- higher age (P= 0.002), and
- higher N-terminal pro-brain natriuretic peptide (NT-proBNP) levels (P< 0.001).
Multivariable linear regression analysis showed that PRA (P= 0.048), and CRP levels (P= 0.006) were independent predictors of 25(OH)D levels.
During follow-up, 155 patients died and 142 patients were rehospitalized.
Kaplan-Meier analysis showed that lower 25(OH)D concentration was associated with an increased risk for the combined endpoint (all-cause mortality and HF rehospitalization; log rank test P= 0.045) and increased risk for all-cause mortality (log rank test P= 0.014).
After adjustment in a multivariable Cox regression analysis, low 25(OH)D concentration remained independently associated with an increased risk for the combined endpoint [hazard ratio (HR) 1.09 per 10 nmol/L decrease; 95% confidence interval (CI) 1.00-1.16; P= 0.040] and
- all-cause mortality (HR 1.10 per 10 nmol/L decrease; 95% CI 1.00-1.22; P= 0.049).
A low 25(OH)D concentration is associated with a poor prognosis in HF patients.
Activation of the RAS and inflammation may confer the adverse effects of low vitamin D levels.
See also VitaminDWiki
- All items in Cardiovascular and Vitamin D
- Overview Cardiovascular and vitamin D
- Cardiovascular Disease is treated by Vitamin D - many studies
219 studies cited this one as of Oct 2022
Heart patients 10 percent more likely to die for every 4 ng less vitamin D – May 2011
- Is vitamin D deficiency related to a higher risk of hospitalization and mortality in veterans with heart failure? - Feb 2020 https://doi.org/10.1016/j.maturitas.2019.11.005
- 1.8X more likely to have Cardio hospitalization if 21 ng vs 41 ng of vitamin D
- Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure - August 2018 https://doi.org/10.1007/s00394-018-1806-y FREE PDF
- Micronutrient Depletion in Heart Failure: Common, Clinically Relevant and Treatable - Nov 2019 10.3390/ijms20225627 FREE PDF - Vitamin D, Omega-3, etc.
3400 visitors, last modified 26 Oct, 2022,This page is in the following categories (# of items in each category)