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HIV therapy reduces Vitamin D levels, supplementation helps - Nov 2019

Effect of vitamin D3 supplementation on HIV-infected adults: a systematic review

Nutrición Hospitalaria

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Nayra do Socorro Caldas Carvalho de Almeida Teixeira1, Beatriz de Mello Pereira1, Iara Katrynne Fonseca Oliveira1, Carlos Henrique Ribeiro Lima1, Cecilia Maria Resende Gongalves de Carvalho2, Ivone Freires de Oliveira Costa Nunes1, Dorcas Lamounier Costa3 and Adriana de Azevedo Paiva2

  • 1 Graduate Program in Food and Nutrition. Universidade Federal do Piaui Brazil.
  • 2 Nutrition Department. Universidade Federal do Piaui. Brazil. Mother and Child Health Department. Universidade Federal do Piaui. Brazil

Introduction: much evidence confirms that vitamin D may be associated with an improvement in CD4 cell counts in HIV-infected individuals, where antiretroviral therapy (ART) is used and associated with decreased 25(OH)D levels.

Objective: to carry out a systematic review on the effect of vitamin D supplementation on HIV-infected adult patients.

Methods: the research was conducted in the databases Science Direct, PubMed, BVS, Scielo Cochrane and Periods, from February to April 2018, with publication limit from 2000 to 2018, without restriction of gender, ethnicity and involving individuals with age older than 18 years. To evaluate the quality of the studies, we used the protocol Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) and the Jadad scale.

Results: the search initially resulted in 198 articles. After the selection process 5 articles were identified as eligible, where they highlight that vitamin D supplementation may be an associated and effective intervention to reduce hypovitaminosis. ART reduces vitamin D3 levels and changes its metabolism, being associated with the risk of mortality. However, adequate levels of 25(OH)D are positively associated with the number of CD4 + cells and the reduction of infection levels.

Conclusion: vitamin D supplementation promotes immune recovery. However, the cases analysed were few, insufficient to fully confirm the
Vitamin D. benefits and recommend supplementation. Therefore, intervention studies are needed to elucidate the role of vitamin D in human protection

Created by admin. Last Modification: Saturday November 9, 2019 18:48:20 GMT-0000 by admin. (Version 11)

Attached files

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