Association of fish and long‐chain omega‐3 fatty acids intakes with total and cause‐specific mortality: prospective analysis of 421 309 individuals
Journal of Internal Medicine Volume 0, Issue 0, https://doi.org/10.1111/joim.12786
Y. Zhang P. Zhuang W. He J. N. Chen W. Q. Wang N. D. Freedman C. C. Abnet J. B. Wang J. J. Jiao
Notes by VitaminDWiki
Wild-caught fatty fish has about 5X more Omega-3 than normal farmed fish
This study ignores wild/farmed
This study considers only a few species - salmon not mentioned
Vitamin D and Omega-3 category starts with
Omega-3 and Vitamin D separately & together help with Autism, Depression, Cardiovascular, Cognition, Pregnancy, Infant, Obesity, Mortality, Breast Cancer, Smoking, Sleep, Stroke, Surgery, Longevity, Trauma, Inflammation, etc
See also - Overview: Omega-3 many benefits include helping vitamin D
- Fish consumption (Omega-3) reduced death rates (421,000 people, 16 years) - July 2018
- Live longer if high Vitamin D or Omega-3 (probably both)
- Women are 30 percent less likely to die if have good level of Omega-3 – Jan 2017
- Vitamin D Omega 3 and Exercise are being used in controlled trial to support healthy ageing – Feb 2012
- Another Nail in the Coffin for Fish Oil Supplements (nope) – JAMA April 2018
- Omega-3 provides many cardiovascular benefits – April 2018
- Omega-3 helps the heart, AHA class II recommendation, more than 1 gm may be needed – March 2018
- 3 days of Omega-3 before cardiac surgery reduced risk of post-op bleeding by half – RCT March 2018
- Perhaps the Omega-3 optimal level is 10 percent, not 8 – Feb 2018
- Omega-3 Cardiovascular meta-analysis has at least 5 major problems – Jan 2018
- Benefits of Omega-3 beyond heart health - LEF Feb 2018
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
- Cardiovascular problems reduced by low dose aspirin and perhaps Omega-3 (also Vit K) – Sept 2017
- Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016
- For every Omega-3 dollar there is a 84 dollar savings in Cardiovascular costs - Foster and Sullivan April 2016
- High dose Omega-3 probably reduces heart problems – American Heart Association – March 2017
- Health problems prevented by eating nuts (perhaps due to Magnesium and or Omega-3) – meta-analysis Dec 2016
- Omega-3 – need more than 1 gram for a short time to reduce Cardiovascular Disease – Nov 2016
- Omega-3 is vital for health, mail-in test is low cost and accurate
- Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015
- Atrial fibrillation sometimes treated by Omega-3 – meta-analysis Sept 2015
- Salmon intervention (vitamin D and Omega-3) improved heart rate variability and reduced anxiety – Nov 2014
- Omega-7 - in addition to Omega-3
- Omega-3 reduces Coronary Heart Disease - infographic June 2014
- Cardiovascular diseases – conflicting data on benefits of Omega-3 and vitamin D – Feb 2014
- Cardiovascular system benefits from both Omega-3 and vitamin D – Dec 2012
- Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues
- Omega-3 does not help heart patients – meta-analysis Sept 2012
- Breast Cancer reduced 20 percent by fish (Omega-3) – meta-analysis Feb 2019
- Breast Cancer rate reduced by 40 percent with Omega-3 – meta-analysis June 2013
- Breast cancer and Omega-3 – perhaps prevention and augment treatment – Aug 2017
- Breast cancer cells killed synergistically by Vitamin D plus Omega-3 (lab) – June 2017
PDF is available free at Sci-Hub 10.1111/joim.12786
Prevailing dietary guidelines recommend regular fish consumption. However, the associations of fish and long‐chain omega‐3 polyunsaturated fatty acids (LCn‐3 PUFAs) intakes with mortality remain unclear.
To examine the associations of fish and LCn‐3 PUFAs intakes with total and cause‐specific mortality.
A total of 240 729 men and 180 580 women from NIH‐AARP Diet and Health Study were prospectively followed‐up for 16 years. Dietary intakes were assessed using a validated NIH Diet History Questionnaire.
A total of 54 230 men and 30 882 women died during 6.07 million person‐years of follow‐up. Higher fish and LCn‐3 PUFAs intakes were significantly associated with lower total mortality (P < 0.0001).
Comparing the highest with lowest quintiles of fish intake, men had
- 9% (95% confidence interval, 6–11%) lower total mortality,
- 10% (6–15%) lower cardiovascular disease (CVD) mortality,
- 6% (1–10%) lower cancer mortality,
- 20% (11–28%) lower respiratory disease mortality and
- 37% (17–53%) lower chronic liver disease mortality, while
- 8% (5–12%) lower total mortality,
- 10% (3–17%) lower CVD mortality and
- 38% (20–52%) lower Alzheimer's disease mortality.
Fried fish consumption was not related to mortality in men whereas positively associated with mortality from all causes (P = 0.011), CVD and respiratory disease in women. LCn‐3 PUFAs intake was associated with 15% and 18% lower CVD mortality in men and women across extreme quintiles, respectively.
Consumption of fish and LCn‐3 PUFAs was robustly associated with lower mortality from major causes. Our findings support current guidelines for fish consumption while advice on non‐frying preparation methods is needed.