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Far fewer vaccination antibodies against Omicron - Dec 14, 2021

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

Preprint https://doi.org/10.1101/2021.12.12.472269

Elisabetta Cameroni1*, Christian Saliba1*, John E. Bowen2*, Laura E. Rosen3*, Katja Culap1, Dora Pinto1, Anna De Marco1, Samantha K. Zepeda2, Julia di Iulio3, Fabrizia Zatta1, Hannah Kaiser3, Julia Noack3, Nisar Farhat3, Nadine Czudnochowski3, Colin Havenar-Daughton3, Kaitlin R. Sprouse2, Josh R. Dillen3, Abigail E. Powell3, Alex Chen3, Cyrus Maher 3, Li Yin3, David Sun3, Leah Soriaga3, Claes Gustafsson4, Nicholas M. Franko5, Jenni Logue5, Najeeha Talat Iqbal6, Ignacio Mazzitelli7, Jorge Geffner7, Renata Grifantini8, Helen Chu5, Andrea Gori9, Agostino Riva10, Olivier Giannini11,12, Alessandro Ceschi11,13,14,15, Paolo Ferrari11,16,17, Alessandra Franzetti-Pellanda18, Christian Garzoni19, Christy Hebner3, Lisa A. Purcell3, Luca Piccoli1, Matteo Samuele Pizzuto1, Alexandra C. Walls2,20, Amalio Telenti2, Herbert W. Virgin3,21,22,23, Antonio Lanzavecchia1,8,23, David Veesler2,20,23, Gyorgy Snell3,23, Davide Corti1,23
1Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
2Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
3Vir Biotechnology, San Francisco, California 94158, USA
4ATUM, Newark, California 94560, USA
5Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA.
6Department of Paediatrics and Child Health, Aga Khan University, Karachi, 74800, Pakistan
7Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Facultad de Medicina, Buenos Aires
C1121ABG, Argentina
8National Institute of Molecular Genetics, Milano, Italy
9Infectious Disease Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy 10Department of Biomedical and Clinical Sciences 'L.Sacco' (DIBIC), Università di Milano, Milan, Italy "Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland "
11Department of Medicine, Ente Ospedaliero Cantonale, Bellinzona, Switzerland 13Clinical Trial Unit, Ente Ospedaliero Cantonale, Lugano, Switzerland
12Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Science of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland
13Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland
"Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland
"Clinical School, University of New South Wales, Sydney, Australia
18Clinical Research Unit, Clinica Luganese Moncucco, 6900 Lugano, Switzerland.
19Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, 6900 Lugano, Switzerland. 20Howard Hughes Medical Institute, Seattle, WA 98195, USA.
21Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis MO 63110
22Department of Internal Medicine, UT Southwestern Medical Center, Dallas TX 75390
23These authors contributed equally: Herbert W. Virgin, Antonio Lanzavecchia, David Veesler, Gyorgy Snell and Davide Corti

The recently emerged SARS-CoV-2 Omicron variant harbors 37 amino acid substitutions in the spike (S) protein, 15 of which are in the receptor-binding domain (RBD), thereby raising concerns about the effectiveness of available vaccines and antibody therapeutics. Here, we show that the Omicron RBD binds to human ACE2 with enhanced affinity relative to the Wuhan-Hu-1 RBD and acquires binding to mouse ACE2. Severe reductions of plasma neutralizing activity were observed against Omicron compared to the ancestral pseudovirus for vaccinated and convalescent individuals. Most (26 out of 29) receptor-binding motif (RBM)-directed monoclonal antibodies (mAbs) lost in vitro neutralizing activity against Omicron, with only three mAbs, including the ACE2-mimicking S2K146 mAb1, retaining unaltered potency. Furthermore, a fraction of broadly neutralizing sarbecovirus mAbs recognizing antigenic sites outside the RBM, including sotrovimab2, S2X2593 and S2H974, neutralized Omicron. The magnitude of Omicron-mediated immune evasion and the acquisition of binding to mouse ACE2 mark a major SARS-CoV-2 mutational shift. Broadly neutralizing sarbecovirus mAbs recognizing epitopes conserved among SARS-CoV-2 variants and other sarbecoviruses may prove key to controlling the ongoing pandemic and future zoonotic spillovers.

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VitaminDWiki pages with OMICRON in title

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Items found: 27
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Number needed to vaccinate to prevent 1 Omicron death: 30,000 for age 60-70 - Sept 2022 29 Sep, 2022
Compare symptoms of Omicron, Flu and Colds 20 Sep, 2022
Paxlovid trial was done before Omicron on UNvaccinated people - Aug 2022 02 Aug, 2022
Omicron BA.2.75 may replace BA.4 and BA.5 as the most contagious - July 8, 2022 10 Jul, 2022
Infectious diseases in the UK so far this year: Omicron, H5 bird flu, Lassa fever, haemorrhagic fever, monkeypox, and polio – June 2022 28 Jun, 2022
2 Vaccinations provided no protection against Omicron infection 6 months later – New England J. of Medicine – June 2022 25 Jun, 2022
Both Omicron and Monkeypox show evidence of mutation by the human immune system – June 2022 24 Jun, 2022
Omicron mutations to avoid vaccinations may get much worse – Bossche June 2022 19 Jun, 2022
Half as much Long-Haul with Omicron - June 2022 19 Jun, 2022
Half as much Long-Haul with Omicron - June 2022 19 Jun, 2022
89% are vaccinated, but Omicron BA.5 is surging (Portugal) June 2022 07 Jun, 2022
Omicron BA.2.12.1 - US dominate form,100,000 cases daily - May 24, 2022 25 May, 2022
Omicron producing variants 70 X faster than Delta - May 2022 16 May, 2022
Increase in COVID Omicron deaths among vaccinated (CA this time) - March 2022 27 Mar, 2022
Croup (due to viruses) has surged with Omicron - March 2022 22 Mar, 2022
Omicron-1 survives on surfaces 3X longer than original - March 18, 2022 19 Mar, 2022
Omicron-2: in 50 countries, some with Omicron-1 can get it - Jan 29, 2022 29 Jan, 2022
66 percent of COVID Omicron patients in Ontario hospitals are vaccinated - Jan 23, 2022 23 Jan, 2022
Far fewer vaccination antibodies against Omicron - Dec 14, 2021 28 Dec, 2021
Covid-Omicron cases rapidly increasing in the US - Dec 27, 2021 28 Dec, 2021
3rd vaccination against Omicron waning in 10 weeks (2nd jab worthless at 20 weeks - UK data) - Dec 23, 2021 27 Dec, 2021
Most of the World’s Vaccines Likely Won’t Prevent Infection From Omicron - NYT Dec 19, 2021 19 Dec, 2021
The more COVID vaccine jabs, the more Omicron infections - Dec 16, 2021 17 Dec, 2021
Omicron may require fourth vaccine dose, Pfizer says - Dec 10, 2021 17 Dec, 2021
Coronaviruses evolve faster with vaccinations, expect more beyond Omicron - Nov 30, 2021 15 Dec, 2021
Did HIV help Omicron evolve - Dec 10, 2021 14 Dec, 2021
Travel bans will not stop omicron, but may reduce reporting on new variants - Dec 3, 2021 03 Dec, 2021

Created by admin. Last Modification: Tuesday December 28, 2021 01:59:59 GMT-0000 by admin. (Version 13)

Attached files

ID Name Comment Uploaded Size Downloads
16773 Anitbodies, vaccines, variants.jpg admin 20 Dec, 2021 102.26 Kb 439
16767 Anitbodies, vaccines, variants.jpg admin 17 Dec, 2021 133.48 Kb 297
16765 Effective vs variant_compressed.pdf admin 17 Dec, 2021 3.26 Mb 690