Cancer Epidemiol Biomarkers Prev. 2015 Sep 12. pii: cebp.0262.2015. [Epub ahead of print]
Tagliabue E1, Raimondi S2, Gandini S3.
Epidemiologic evidence supported a role for vitamin D and vitamin D receptor (VDR) polymorphisms in cancer risk. Beyond VDR, the biological effects of vitamin D are mediated by the vitamin D binding protein (DBP), a key protein in vitamin D metabolism. Furthermore, the gene encoding the DBP (GC, Group-specific component) has an important role in vitamin D pathway. Several studies investigated DBP serological levels and GC polymorphisms in association with cancer risk with controversial results. Thus we carried out a meta-analysis to investigate these associations.
We included 28 independent studies concerning: basal cell carcinoma, bladder, breast, colon-rectum, endometrium, liver, esophagus, stomach, melanoma, pancreas, prostate and kidney. Through random effect models we calculated the Summary Odd Ratios (SORs) for serum DBP and the GC polymorphisms rs2282679, rs12512631, rs7041, rs4588, rs17467825, rs1155563 and rs1352844.
We found a borderline decrease in cancer risk for subjects with high compared to low levels of DBP (SOR;95%CI:0.75;0.56-1.00). Dose-response meta-analysis indicate a non-significant decrease risk for an increase of 1,000 nmol/L of DBP: (SOR;95%CI:0.96;0.91-1.01). We found no significant alterations in cancer risk for subjects carrying any of the studied GC polymorphisms compared to wild-type subjects both in the main analysis and in analyses stratified by cancer type and ethnicity.
We found trends toward significance suggesting a role of DBP in cancer etiology, that should be confirmed in further studies.
To our knowledge, this is the first study to investigate GC polymorphisms and DBP serological levels in association with any type of cancer.
Copyright © 2015, American Association for Cancer Research.
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