- Senior skin produces 4X less Vitamin D for the same sun intensity
- Seniors have fewer vitamin D receptor genes as they age
Receptors are needed to get Vitamin D in blood actually into the cells - Many other Vitamin D genes decrease with age
- Since many gene activations are not detected by a blood test,
more Vitamin D is often needed, especially by seniors - Seniors are indoors more than when they were younger
not as agile, weaker muscles; frail, no longer enjoy hot temperatures - Seniors wear more clothing outdoors than when younger
Seniors also are told to fear skin cancer & wrinkles - Seniors often take various drugs which end up reducing vitamin D
Some reductions are not detected by a vitamin D test of the blood
statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc - Seniors often have one or more diseases that consume vitamin D
osteoporosis, diabetes, Multiple Sclerosis, Cancer, ... - Seniors generally put on weight as they age - and a heavier body requires more vitamin D
- Seniors often (40%) have fatty livers – which do not process vitamin D as well
- Reduced stomach acid means less Magnesium is available to get vitamin D into the cells
- Vitamin D is not as bioavailable in senior intestines
- Seniors with poorly functioning kidneys do not process vitamin D as well
- Glutathione (which increases Vitamin D getting to cells) decreases with age
Seniors category has431 items
Table of Contents for the rest of this page
- VitaminDWiki - Genetics chart shows the vitamin D genes
- Some genes reduce Vitamin D (Calcidiol) in blood from getting to senior cells
- VitaminDWiki -
11 studies in both categories Seniors and Vitamin D Receptor - Skin of seniors generates 75% less Vitamin D
- How does the body's ability to produce vitamin D change with age - Perplexity AI July 2024
- See also VitaminDWiki
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VitaminDWiki - Genetics chart shows the vitamin D genes
Some genes reduce Vitamin D (Calcidiol) in blood from getting to senior cells
- Genes which regulate active vitamin D worsen with age – Oct 2016
- No response to vitamin D 7X more likely if poor CYP24A1 or VDBP genes - Feb 2023
- Vitamin D non-responders may have one or more poor genes: GC, LIPC, CYP24A1, and PDE3B – Oct 2022
- 3X higher risk of oral cancer if CYP27B1 and CYP24A1 genes were different – May 2012
- Eye vitamin D may not be associated with blood VitD, but is associated with CYP27B1 and CYP24A1 – Nov 2019
- Kidney Stones are related to poor genes – example of CYP24A1 (Vitamin D) – Nov 2019
- Acute Coronary Syndrome is associated with poor Vitamin D genes (CYP27B1, CYP24A1) – Nov 2019
- CYP24A1 gene in cancer cells may actually remove vitamin D from the blood – Oct 2012
- Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015
- Prostate Cancer – Vitamin D – CYP27B1 – CYP24 – June 2011
VitaminDWiki -
11 studies in both categories Seniors and Vitamin D Receptor This list is automatically updated
- Vitamin D Receptors in muscles decrease with age in those with Osteoporosis - 2018
- Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020
- Parathyroid increase with age associated with worsening Vitamin D genes – April 2020
- Reduced muscle function in mice lacking Vitamin D Receptors in muscles – June 2019
- Vitamin D and Ageing (29 page chapter, VDR decreases with age) – Feb 2019
- Less vitamin D gets to cells as you age - fewer Vitamin D Receptors - 2004
- Aging leads to a decrease of vitamin D getting to cells – Sept 2017
- Sepsis is 13 X more likely if poor Vitamin D Receptor – April 2017
- Centenarians have good Vitamin D Receptor genes (or take lots of vitamin D) – March 2016
- 13 reasons why many seniors need more vitamin D (both dose and level) - July 2023
- Sarcopenia (muscle loss) fought by Vitamin D, exercise and protein - many studies
Skin of seniors generates 75% less Vitamin D
Wonder what % of the "diseases of aging" are due to low vitamin D?The Blue Zone books show seniors in their 90's who are active in gardens (getting lots of vitamin D - as well as exercise, good food, etc.)
How does the body's ability to produce vitamin D change with age - Perplexity AI July 2024
The body's ability to produce vitamin D decreases with age due to several physiological changes. Here are the main factors contributing to this decline:
Decreased Skin Production- Reduction in 7-dehydrocholesterol: The concentration of 7-dehydrocholesterol, the precursor to vitamin D, in the epidermis decreases significantly with age. Studies show that the levels can drop by more than 50% from age 20 to 80.
- Reduced Response to UV Light: Older skin has a diminished capacity to produce previtamin D3 when exposed to ultraviolet B (UVB) light. This results in a twofold decrease in the skin's ability to produce vitamin D3 in older individuals compared to younger ones.
Decreased Sun Exposure
- Lifestyle Factors: Older adults, especially those who are institutionalized or housebound, tend to have less exposure to sunlight, which further reduces their ability to synthesize vitamin D.
Metabolic Changes
- Reduced Renal Function: Aging is associated with a decline in kidney function, which affects the conversion of 25-hydroxyvitamin D (25(OH)D) to its active form, 1,25-dihydroxyvitamin D (1,25(OH)2D). This conversion is crucial for maintaining adequate vitamin D levels in the body.
- Intestinal Calcium Absorption: There is a decrease in the efficiency of calcium absorption in the intestines with age, which can be exacerbated by vitamin D deficiency.
Increased Risk of Deficiency
- Vitamin D Resistance: Older adults may develop a form of vitamin D resistance, where their bodies are less responsive to the vitamin D available, further complicating the maintenance of adequate levels.
- Higher Catabolism: There may be an increase in the catabolism (breakdown) of vitamin D with age, which can contribute to lower levels of the vitamin in the body.
Quantitative Decline
- Rate of Decline: Research indicates that there is approximately a 13% decrease in the production of vitamin D3 per decade of life. By the age of 70, the production of vitamin D3 is roughly half of what it was at age 20.
Supplementation and Management
- Supplementation: Given these challenges, vitamin D supplementation is often recommended for older adults to maintain adequate levels and support bone health. Combining vitamin D with calcium supplementation can help reduce the risk of fractures and other complications associated with deficiency.
In summary, aging significantly impacts the body's ability to produce and metabolize vitamin D due to decreased skin production, reduced sun exposure, and metabolic changes. These factors collectively increase the risk of vitamin D deficiency in older adults, making supplementation an important consideration for maintaining health.
click here for references, images, etc
See also VitaminDWiki
- Overview Seniors and Vitamin D
- 20 reasons for not taking Vitamin D debunked
- Many diseases of aging are associated with low vitamin D – Dec 2014
- Many reasons why vitamin D deficiency has become epidemic 40 reasons as of Feb 2024
- Hypothesis: Sarcopenia and other senior problems are related to low gastric acid
- Elderly often trapped in vitamin D vicious circles
- 4700 IU of vitamin D needed by most seniors – an equation -July 2014
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