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Arteries and Atherosclerosis and Vitamin D - many studies

74+ VitaminDWiki pages with ARTERIES OR ATHEROSCLEROSIS OR CALCIFICATION in title

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Items found: 74

Perplexity & Deep Reasoning on Vitamin D and Atherosclerosis - Feb 2025

Starts with
Atherosclerosis, characterized by chronic arterial plaque formation, remains a leading cause of cardiovascular morbidity and mortality. Emerging evidence positions vitamin D as a critical modulator of atherosclerotic pathways, influencing endothelial function, immune regulation, and vascular homeostasis. This review synthesizes mechanistic insights and clinical evidence to elucidate how vitamin D deficiency exacerbates atherosclerosis while exploring the therapeutic potential of supplementation.
Therapeutic Implications and Future Directions
Supplementation Strategies
Current evidence supports targeting 25(OH)D levels of 30–50 ng/mL for cardiovascular protection. Doses of 2,000–4,000 IU/day are generally safe, though obese individuals and those with malabsorption may require higher intake. Combining vitamin D with calcium warrants caution, as co-supplementation may blunt blood pressure benefits despite enhancing PTH suppression.

Personalized Approaches
Genomic studies identify VDR polymorphisms (e.g., BsmI, FokI) that influence vitamin D responsiveness. Carriers of the FokI ff genotype exhibit stronger anti-inflammatory effects, suggesting pharmacogenomic tailoring could optimize outcomes1213. Subgroup analyses also indicate heightened benefits in deficient populations with elevated hs-CRP or hypertension

Novel Pathways and Senescence
Emerging research links vitamin D to cellular senescence—a driver of vascular aging. Vitamin D mitigates senescent cell accumulation in plaques by upregulating klotho and suppressing p16INK4a, potentially delaying atherosclerosis progression. Local intracrine signaling within adipose tissue and macrophages may also modulate plaque stability independently of systemic levels, opening avenues for tissue-targeted therapies

VitaminDWiki – Hypertension category contains

170 items in the category HYPERTENSION

see also
Overview Overview Hypertension and Vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
Some interesting Hypertension studies

VitaminDWiki – Metabolic Syndrome contains

107 items

See also

344+ VitaminDWiki Cardiovascular pages with VITAMIN D in the title

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Items found: 381
Title Modified
Best heart geometry associated with vitamin D of 30-37 ng – Oct 2012 30 Oct, 2012
2500 IU vitamin D did not reduce risk of CVD risk in 4 months - May 2012 29 Oct, 2012
Vitamin D reduced CVD risk - systematic review 2010 26 Oct, 2012
Low levels of vitamin D associated with all cause mortality – Oct 2012 25 Oct, 2012
Hypertension experts want still more vitamin D proof – Oct 2012 18 Oct, 2012
Vertebral fracture 3X more likely with aortic calcification – Vitamins D3 and K2 Sept 2012 17 Oct, 2012
800 IU Vitamin D doesn't prevent heart attack or cancer – Dec 2011 16 Oct, 2012
Coronary Artery Disease predicted by low levels of vitamin D – April 2012 16 Oct, 2012
Petrie dish experiment confirms that active vitamin D reduces arterial inflammation – Aug 2012 23 Aug, 2012
Echocardiograms confirm problems with low vitamin D – May 2012 14 Aug, 2012
Death in less than 2 years of Heart Failure associated with low vitamin D - April 2012 08 Aug, 2012
100000 IU vitamin D did not help Peripheral Arerial Disease in one month – July 2012 07 Aug, 2012
1000 IU vitamin D did not reduce cardiovascular risk factors – Aug 2012 04 Aug, 2012
Cardiovascular Disease and vitamin D - April 2012 21 Jul, 2012
High triglycerides in Metabolic Syndrome associated with low Vitamin D – July 2012 12 Jul, 2012
UVB increasing vitamin D to 34 ng did not lower blood pressure – June 2011 26 Jun, 2012
Babies Receive Heart Transplants Instead of Vitamin D Treatment 25 Jun, 2012
11 ng less vitamin D increases hypertension probability by 14 percent – Nov 2010 23 Jun, 2012
Did not find association between vitamin D and cardiovascular mortality – Sept 2010 23 Jun, 2012
Vitamin D interactions with cardiovascular disease - unsure – April 2012 07 May, 2012
96 percent of heart failure patients had less than 30 ng of vitamin D – March 2011 28 Apr, 2012
Old concern about high vitamin D and atherosclerosis – 2003 08 Apr, 2012
Statistical paradox of vitamin D deficiency and heart disease – March 2012 03 Apr, 2012
Cardiovascular problems for teens if low levels of vitamin D – March 2012 16 Mar, 2012
Low vitamin D associated with obesity-related diseases for ethnic minorities – Sept 2011 18 Feb, 2012
Vitamin D deficiency might cause diabetes and cardiovascular diseases – Jan 2012 01 Feb, 2012
Yup, 2500 IU of vitamin D does not help the heart in the short term - Nov 2011 19 Jan, 2012
Cardiovascular disease may be reduced by vitamin D – June 2011 19 Jan, 2012
Review of Calcium – Vitamin D - Cardiovascular Disease – June 2011 19 Jan, 2012
More than 600 IU of vitamin D reduced male CVD risk by 16 percent – June 2011 17 Jan, 2012
Vitamin D helped cardiovascular patients in many ways– Nov 2011 29 Nov, 2011
Improved blood flow in blacks with just 2000 IU of vitamin D – Feb 2011 22 Nov, 2011
Lack of vitamin D associated with many cardiovascular problems – May 2011 11 Nov, 2011
Vitamin D relationship with HDL and LDL is uncertain – Oct 2011 17 Oct, 2011
CV event 56 percent more likely after vascular surgery if low on vitamin D – Oct 2011 17 Oct, 2011
Table of outcomes for seniors vs vitamin D level 04 Sep, 2011
Bypass surgery and vitamin D – Nov 2010 03 Sep, 2011
Calcium can create heart problems - vitamin D neutral - Aug 2011 01 Sep, 2011
Low vitamin D may contribute to Peripheral Arterial Disease – June 2010 30 Aug, 2011
Potential for vitamin D receptor agonists in the treatment of cardiovascular disease 03 Aug, 2011
Vitamin D is a promising way to deal with atherosclerosis – Aug 2010 03 Jul, 2011
Atherosclerosis associated with low vitamin D – June 2011 03 Jul, 2011
Vitamin D might deal with atherosclerosis – Jan 2011 03 Jul, 2011
Increasing vitamin D levels will probably reduce CVD and mortality – June 2011 22 Jun, 2011
Patent for patients of Chronic Heart Failure includes vitamin D – June 2011 16 Jun, 2011
Monkeys each got 1000 IU daily - but vitamin D in blood varied with HDL – May 2011 20 May, 2011
Heart Failure associated with vitamin D deficiency – Feb 2011 01 Apr, 2011
Not yet certain that vitamin D reduces cardiovascular and diabetes in blacks – Mar 2011 13 Mar, 2011
Calcium without vitamin D increased heart risk by 30 percent - Jan 2011 20 Feb, 2011
Review is unsure if supplementing vitamin D will decrease heart failure – Feb 2011 13 Feb, 2011
Question - Does more vitamin D make veins less stiff - Nov 2007 27 Jan, 2011
Calcium with Vitamin D2 then D3 helps A-A after heart failure – Jan 2011 18 Jan, 2011
Why we need large-scale heart trials of vitamin D - Dec 2010 02 Jan, 2011
Cardiology diseases highly associated with low vitamin D – Oct 2010 01 Jan, 2011
Editorial on Vitamin D deficiency– Current Drug topics – Jan 2011 13 Dec, 2010
Review of heart failure and vitamin D mechanisms – Jan 2011 13 Dec, 2010
Race CVD and Vitamin D - Newsletter Mar 2010 05 Nov, 2010
Vitamin D is important for cardiovascular health – Sept 2010 18 Sep, 2010
Vitamin D reduces both death rate and cardiovascular disease – Sept 2010 18 Sep, 2010
Meta-analysis unsure if vitamin D can prevent cardiovascular disease – Sept 2010 18 Sep, 2010
Heart Failure 3X more likely if less than 30 ng of vitamin D – Sept 2010 16 Sep, 2010
Review of vitamin D and heart failure – Aug 2010 02 Sep, 2010
Lack of vitamin D is a predictor of heart failure – Sept 2010 02 Sep, 2010
Vitamin D deficiency highly correlated with cardiovascular problems – Aug 2010 30 Aug, 2010
Twice as likely to die of cardiovascular disease if low on vitamin D – July 2010 06 Aug, 2010
Heart attacks increased by 30% in those taking 500 mg of Calcium without vitamin D – July 2010 31 Jul, 2010
The prognostic value of vitamin D in heart failure – July 2010 28 Jul, 2010
Aortas of 16 year old blacks helped by 2000 IU of vitamin D – July 2010 28 Jul, 2010
40% more likely to die of heart problems if have low level of vitamin D – Jan 2010 07 Jul, 2010
Vitamin D and cardiovascular disease - Systematic review June 2010 07 Jul, 2010
Cardiovascular Systematic Review of Vitamin D- Mar 2010 06 Jul, 2010
Low Vitamin D associated with cardiovascular disease – June 2010 30 Jun, 2010
Vitamin D lower than 15 ng associated with almost 3X more depression in seniors with CVD – June 2010 26 Jun, 2010
Vitamin D less than 15 ng did not predict additional cardiovascular disease events – June 2010 26 Jun, 2010
Vitamin D deficient elderly are 2X more likely to die of CVD - Jan 2010 20 Jun, 2010
5700 IU daily equivalent vitamin D for obese did not reduce cardiovascular risk factors – June 2010 19 Jun, 2010
Vitamin D deficiency associated with many diseases – Greece April 2010 09 Jun, 2010
1000 IU vitamin D might prevent cardiovascular events – March 2010 02 Jun, 2010
Can vitamin D improve quality of life for seniors with heart failure -2010 02 Jun, 2010
The impact of vitamin D deficiency on diabetes and cardiovascular risk -April 2010 16 May, 2010
Therapeutic window for vitamin D and chronic kidney disease 25 Apr, 2010

133,000 medical papers on Atherosclerosis and "Vitamin D" (Feb 2025)

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  • Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure - Sept 2020 - DOI: 10.3390/ijms21186483 FREE PDF
  • Vitamin D and Atherosclerotic Cardiovascular Disease - April 2019 https://doi.org/10.1210/jc.2019-00194 FREE PDF
  • Clinical and biomarker modifiers of vitamin D treatment response: the Multi-Ethnic Study of Atherosclerosis - March 2022, https://doi.org/10.1093/ajcn/nqab390 FREE PDF
  • Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women - Sept 2021 https://doi.org/10.3390/biology10111139 FREE PDF
  • The Effect of Vitamin D on Coronary Atherosclerosis: A Propensity Score Matched Case–Control Coronary CTA Study - July 2021 https://doi.org/10.3390/jcdd8080085    PDF
    • "Patients with serum vitamin D (OH) levels >60 ng/mL had higher plaque density (p = 0.04), indicating more calc ified and less vulnerable plaque. Conclusions: In this retrospective case–control cohort study, vitamin D supplementation was associated with less high-risk plaque, less non-calcified plaque burden, and a higher calcified plaque independent of CV risk factors."
  • Assessment of Subclinical Atherosclerosis in Vitamin D Deficiency - June 2019. | DOI: 10.1097/RUQ.0000000000000386 PDF is behind paywall
  • Vitamin D level is associated with severity of coronary artery atherosclerosis and incidence of acute coronary syndromes in non-diabetic cardiac patients - March 2017 DOI: https://doi.org/10.5114/aoms.2019.83291  PDF

44,400 medical papers on Atherosclerosis and "Vitamin K" (Feb 2025)

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  • An L-shaped relationship between dietary vitamin K and atherosclerotic cardiovascular disease - June 2024 FREE PDF
  • Quantifying dietary vitamin K and its link to cardiovascular health: a narrative review - March 2020    PDF
  • Vitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials - Sept 2020 9; https://doi.org/10.3390/nu12102909    PDF
    • "While vitamin K supplementation clearly improves the carboxylation of dephosphoylated MGP, its role in mitigating vascular calcification is uncertain, based on current evidence."
  • Extent of arterial calcification by conventional vitamin K antagonist treatment - Oct, 2020    PDF
  • Vitamin K supplementation and vascular calcification: a systematic review and meta-analysis of randomized controlled trials- May 2023    PDF

VitaminDWiki - 26 studies in both categories Cardiovascular and Vitamin K

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Arteries and Atherosclerosis and Vitamin D - many studies        
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19736 vit K meta_CompressPdf.pdf admin 03 Jul, 2023 481.08 Kb 252
19735 Extent of arterial calcification_CompressPdf.pdf admin 03 Jul, 2023 422.96 Kb 214
19734 Vitamin K and Calcification_CompressPdf.pdf admin 03 Jul, 2023 133.60 Kb 120
19733 Vitamin K CVD_CompressPdf.pdf admin 03 Jul, 2023 266.82 Kb 247
19732 Quantifying dietary vitamin K and its link to cardiovascular heal_CompressPdf.pdf admin 03 Jul, 2023 213.94 Kb 222
19731 AOMS_Art_35959-10.pdf admin 03 Jul, 2023 105.89 Kb 303
19730 Atherosclerosis Propensity_CompressPdf.pdf admin 03 Jul, 2023 283.72 Kb 271